NFL · 3 days ago

Ranking the Top 15 NFL Games For the 2026 Season

Danny Mogollon

Host · Writer

15) New England Patriots @ Detroit Lions
Patriots @ Lions Matchup
- When: Week 10
- Where: Munich, Germany
The New England Patriots and Detroit Lions will play this year's Germany game, with both teams having significant playoff aspirations. By mid-November, these teams should both be vying for playoff positioning, making this a very compelling matchup.

Patriots @ Lions Betting Odds
- Spread: Lions -1.5 (-102)
- Total: 49.5
- Moneyline: Lions -112 | Patriots -104
1) Los Angeles Rams @ Philadelphia Eagles
Rams @ Eagles Matchup
- When: Week 4
- Where: Philadelphia
The Eagles and Rams are widely viewed as Seattle's top competition in the NFC. These two teams have given us classics in prior playoff matchups, and this game will have a playoff-type atmosphere in Philadelphia, with both teams looking to make a statement.

49ers @ Rams Betting Odds
- Spread: TBD
- Total: TBD
- Moneyline: TBD
2) Kansas City Chiefs @ Seattle Seahawks
Chiefs @ Seahawks Matchup
- When: Week 7
- Where: Seattle
No matter when in the season it occurs, this matchup will have plenty of implications on the line for both teams. Have the Seahawks completely overtaken the Chiefs in league supremacy? This game will be a great test.

Chiefs @ Seahawks Betting Odds
- Spread: TBD
- Total: TBD
- Moneyline: TBD
3) San Francisco 49ers @ Los Angeles Rams
49ers @ Rams Matchup
- When: Week 1
- Where: Melbourne, Australia
The 49ers and Rams always deliver extremely compelling games and explosive play-making. The NFL's first international game this season will take place in Australia, and the fans should be getting themselves a treat.

49ers @ Rams Betting Odds
- Spread: Rams -2.5 (-115)
- Total: 49.5
- Moneyline: Rams -146 | 49ers +124
4) New England Patriots @ Seattle Seahawks
Patriots @ Seahawks Matchup
- When: Week 1
- Where: Seattle
A rematch of the previous year's Super Bowl is always a treat to watch. While the Seahawks' opponent for their Week 1 game has yet to be announced, I would not be surprised if we see the Patriots travel to Seattle and similarly start the season as the Broncos did after they hosted the Panthers in Week 1 of 2016, fresh off defeating them in Super Bowl 50.

Patriots @ Seahawks Betting Odds
- Spread: Seahawks -4.5 (-105)
- Total: 44.5
- Moneyline: Seahawks -205 | Patriots +172
5) Dallas Cowboys @ New York Giants
Cowboys @ Giants Matchup
- When: Week 1
- Where: East Rutherford
The John Harbaugh era gets off to an electrifying start in NY, as the Giants will host the Cowboys in the season's Sunday Night opener. The Giants remain one of the more intriguing storylines heading into this season, and beating one of your arch rivals would be a dream start.

Cowboys @ Giants Betting Odds
- Spread: Cowboys -2.5 (-120)
- Total: 47.5
- Moneyline: Cowboys -148 | Giants +126
6) Buffalo Bills @ Denver Broncos
Bills @ Broncos @ Matchup
- When: Week 16
- Where: Denver
Last season's postseason battle between these two saw the Broncos' defense force Josh Allen into multiple turnovers, and Bo Nix go down with an injury that would end his season. Nobody would be surprised if they saw each other again in this year's playoffs, making this regular-season matchup very compelling.

Broncos @ Bills Betting Odds

Spread: Bills -1.5 (-115)

Total: 46.5

Moneyline: Bills -132 | Broncos +112
7) Chicago Bears @ Seattle Seahawks
Bears @ Seahawks Matchup
- When: Week 8
- Where: Seattle
The Chicago Bears are one of the up-and-coming teams in the NFC. They will have a true measuring stick game going to Seattle to take on the defending Super Bowl Champions, in a matchup of two of the conference's top teams.

Bears @ Seahawks Betting Odds
- Spread: TBD
- Total: TBD
- Moneyline: TBD
8) Philadelphia Eagles @ Dallas Cowboys
Eagles @ Cowboys Matchup
- When: Week 12
- Where: Arlington
In one of the NFL's fiercest rivalries, this year's Thanksgiving matchup in Dallas between the Cowboys and Eagles has the potential to be a holiday classic, especially if both are in the thick of the NFC East race.

Eagles @ Cowboys Betting Odds
- Spread: Cowboys -1.5 (-104)
- Total: 49.5
- Moneyline: Cowboys -116 | Eagles -102
9) San Francisco 49ers @ Kansas City Chiefs
49ers @ Chiefs Matchup
- When: Week 16
- Where: Kansas City
In a rematch of Super Bowls LIV and LVIII, the 49ers travel to Arrowhead to take on the Chiefs. Fireworks are a fixture of every game between these two teams, and this year's matchup figures to be no different. Mike Shanahan vs. Andy Reid can usually be penciled in as must-see TV.

49ers @ Chiefs Betting Odds
- Spread: TBD
- Total: TBD
- Moneyline: TBD
10) Detroit Lions @ Buffalo Bills
Lions @ Bills Matchup
- When: Week 2
- Where: Buffalo
The first Al Michaels/Kirk Herbstreit broadcast of 2026 will take place in Buffalo, as the Bills host the Detroit Lions. Both teams would consider last season a disappointment, and are hungry to show they can compete for a Super Bowl in 2026.

Lions @ Bills Betting Odds
- Spread: TBD
- Total: TBD
- Moneyline: TBD
11) Buffalo Bills @ Green Bay Packers
Bills @ Packers Matchup
- When: Week 14
- Where: Green Bay
There always seems to be one classic at Lambeau Field every year, and this matchup has the makings of a potential classic. Considering the Bills are more than accustomed to cold-weather conditions, making this a late-season affair would make it even more intriguing.

Bills @ Packers Betting Odds
- Spread: TBD
- Total: TBD
- Moneyline: TBD
12) Denver Broncos @ Kansas City Chiefs
Broncos vs. Chiefs Matchup
- When: Week 1
- Where: Kansas City
Assuming Patrick Mahomes makes his return to the field for Week 1, it's hard to think of a better way to kick off the Monday Night Football season with a matchup of bitter rivals in the AFC West. Kansas City will be sure to have revenge on its mind.

Broncos vs. Chiefs Betting Odds
- Spread: Chiefs -2.5 (-110)
- Total: 43.5
- Moneyline: Chiefs -142 | Broncos +120
13) Philadelphia Eagles @ Jacksonville Jaguars
Eagles @ Jaguars Matchup
- When: Week 5
- Where: London, U.K.
In the first of two consecutive games in London, the Jacksonville Jaguars and the Philadelphia Eagles will face off in a mid-October showdown of two teams that have plans of making deep runs.

Eagles @ Jaguars Betting Odds
- Spread: Eagles -1.5 (-108)
- Total: 44.5
- Moneyline: Eagles -124 | Jaguars +105
14) Houston Texans @ Jacksonville Jaguars
Texans @ Jaguars Matchup
- When: Week 6
- Where: London, U.K.
Jacksonville will round out its second of two brutal games in a row as they take on its division rival, the Houston Texans, in London. This matchup figures to go a long way in determining the AFC South winner.

Texans @ Jaguars Betting Odds
- Spread: Jaguars -1.5 (+100)
- Total: 40.5
- Moneyline: Jaguars -108 | Texans +108
15) New England Patriots @ Detroit Lions
Patriots @ Lions Matchup
- When: Week 10
- Where: Munich, Germany
The New England Patriots and Detroit Lions will play this year's Germany game, with both teams having significant playoff aspirations. By mid-November, these teams should both be vying for playoff positioning, making this a very compelling matchup.

Patriots @ Lions Betting Odds
- Spread: Lions -1.5 (-102)
- Total: 49.5
- Moneyline: Lions -112 | Patriots -104
1) Los Angeles Rams @ Philadelphia Eagles
Rams @ Eagles Matchup
- When: Week 4
- Where: Philadelphia
The Eagles and Rams are widely viewed as Seattle's top competition in the NFC. These two teams have given us classics in prior playoff matchups, and this game will have a playoff-type atmosphere in Philadelphia, with both teams looking to make a statement.

49ers @ Rams Betting Odds
- Spread: TBD
- Total: TBD
- Moneyline: TBD