Buffalo Bills 2022 Schedule: Dates, Times, & Analysis

Buffalo Bills fans have likely run out of superlatives to describe last season’s heartbreaking Divisional Round loss to the Kansas City Chiefs. Josh Allen and company were 13 seconds away from advancing to their second-straight AFC Championship Game. 

As gut-wrenching as that defeat might have been, the Bills reloaded in the offseason and enter the upcoming campaign as odds-on Super Bowl favorites (+600). To that end, Buffalo was awarded a maximum of five prime-time games, with matchups against the Los Angeles Rams, Tennessee Titans, Green Bay Packers, New England Patriots, and Cincinnati Bengals.

In what is truly a new era of Bills football, here is Buffalo’s 2022 regular season schedule.

Week 1 @ Los Angeles Rams

Date: Thursday, September 8
Time: 8:20 p.m. ET

The Bills and Rams kick off the 2022 regular season in what should be an exciting opening tilt. 

Week 2 vs. Tennessee Titans

Date: Monday, September 19
Time: 7:15 p.m. ET

Buffalo’s home opener comes against a Titans squad that edged the Bills 34-31 last season. 

Tennessee running back Derrick Henry has run for 278 yards and six touchdowns in his last three games against Buffalo. 

Week 3 @ Miami Dolphins

Date: Sunday, September 25
Time: 1:00 p.m. ET

The Bills square off against Tyreek Hill and the new-look Miami Dolphins. Hill and fellow wideout Jaylen Waddle present a stern test for a Buffalo secondary that is likely to be without All-Pro cornerback Tre’Davious White, who continues to recover from last year’s torn ACL. 

Week 4 @ Baltimore Ravens

Date: Sunday, October 2
Time: 1:00 p.m. ET

Lamar Jackson and company were ravaged by injuries last season. Now healthy, the Ravens should again be a contender in the AFC and a team Buffalo cannot take lightly.

Week 5 vs. Pittsburgh Steelers

Date: Sunday, October 9
Time: 1:00 p.m.

Pittsburgh stunned the Bills 23-16 in Week 1 of last season. While Steelers head coach Mike Tomlin has yet to announce a starting quarterback, all signs point to former Buffalo QB Mitch Trubisky being under center. 

Week 6 @ Kansas City Chiefs

Date: Sunday, October 16
Time: 4:25 p.m. ET

One of the most highly anticipated games on the entire schedule. This rematch needs little explanation.  

Week 7 BYE

Week 8 vs. Green Bay Packers

Date: Sunday, October 30
Time: 8:20 p.m. ET

Josh Allen vs. Aaron Rodgers in prime time? NFL fans will take that any day of the week.

Week 9 @ New York Jets

Date: Sunday, November 6
Time: 1:00 p.m. ET

Buffalo swept New York last season, outscoring the Jets 72-27 over the two contests. While Robert Saleh’s squad should be much improved following a strong offseason, the Bills will be heavily favored.

Week 10 vs. Minnesota Vikings

Date: Sunday, November 13
Time: 1:00 p.m. ET

Bills star wideout Stefon Diggs battles his old team for the first time since being acquired by Buffalo in 2020. Diggs and Minnesota’s Justin Jefferson make for an exciting receiver duel.

Week 11 vs. Cleveland Browns

Date: Sunday, November 20
Time: 1:00 p.m. ET

As things currently stand, the Browns will have quarterback Deshaun Watson under center. However, with the NFL appealing Watson’s initial six-game suspension, a Jacoby Brissett-led Cleveland squad remains a possibility. 

Week 12 @ Detroit Lions

Date: Sunday, November 24
Time: 12:30 p.m. ET

For the third time in four seasons, the Bills will be a part of the NFL’s annual Thanksgiving Day slate. Buffalo battles a Detroit Lions team that performed far better than last year’s 3-13-1 record suggests and should take another step forward in their second season under head coach Dan Campbell.

Week 13 @ New England Patriots

Date: Sunday, December 1
Time: 8:15 p.m. ET

The Bills have won four of the past five meetings, including last season’s 47-17 shellacking in the AFC Wild Card Round. An important divisional matchup nonetheless, particularly this late in the year.

Week 14 vs. New York Jets

Date: Sunday, December 18
Time: 1:00 p.m. ET

Buffalo hosts the Jets in the Bills’ first divisional home game of the season. It’s challenging to see Sean McDermott’s squad letting this one get away. 

Week 15 vs. Miami Dolphins

Date: Sunday, December 18
Time: TBD

A potentially crucial divisional showdown with a Dolphins team that is expected to be right in the thick of the AFC playoff race.

Week 16 @ Chicago Bears

Date: Saturday, December 24
Time: 1:00 p.m. ET

Chicago is in full-on rebuild mode. A must-have for the Bills, who will likely be battling for the AFC’s No.1 seed and a first-round bye. 

Week 17 @ Cincinnati Bengals

Date: Monday, January 2
Time: 8:30 p.m. ET

Buffalo’s final prime-time outing of the season comes against Joe Burrow and the Cincinnati Bengals in a potential AFC Championship Game preview. 

Week 18 vs. New England Patriots

Date: Sunday, January 8
Time: TBD

Assuming both teams still have something to play for, Bills fans would love nothing more than to put a dent in New England’s playoff hopes.