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Guardians vs Giants Final Score — Mar 21

Odds & predictions, free picks, prop bets, and injury updates

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Cleveland Guardians

7

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San Francisco Giants

10

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Frequently Asked Questions

What are the latest odds and run line for Cleveland Guardians vs. San Francisco Giants?

The San Francisco Giants are favored by 1.5 runs on the run line (-1.5), while the Cleveland Guardians are underdogs +1.5 runs. The moneyline is Cleveland Guardians +134 and San Francisco Giants -164. The over/under is set at 11.5 runs.