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Astros vs. Cubs Game Preview: Live MLB Prediction, Odds & Picks

🟢Next update in: 12 minutes from now

Astros vs. Cubs preview (May 22). Updated every 15 minutes with current odds (Cubs -142), Dansby Swanson props & pitching matchup: Spencer Arrighetti vs. Jameson Taillon (probable).

Today's Data Snapshot

Today's Data Snapshot
Market Source:FanDuel
Primary Prediction:Cubs -1.5
Key Player Prop:Dansby Swanson Over 0.5 RBIs
Probable Pitchers:Spencer Arrighetti (RHP; 1.50 ERA) vs. Jameson Taillon (RHP; 4.97 ERA)
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Houston Astros

20-31

Apple TV+

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Chicago Cubs

29-21

GAME PREDICTIONS Latest News

GAME PREDICTIONS

PREDICTED GAME OUTCOME

Cubs logoCubs win by
0.8 Runs

CHANCE TO WIN

 logo41%
59%Cubs logo

Model Picks

Cubs

Cubs -1.5

Total

Total O 7

Insights provided by the SportsGrid betting model

LATEST PLAYER PROPS

LATEST PLAYER PROPS

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HOU

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CHC

05/22 ·2:20 PM

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HOU

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CHC

05/22 ·2:20 PM

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HOU

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CHC

05/22 ·2:20 PM

Frequently Asked Questions

What are the latest odds and run line for Houston Astros vs. Chicago Cubs?

The Chicago Cubs are favored by 1.5 runs on the run line (-1.5), while the Houston Astros are underdogs +1.5 runs. The moneyline is Houston Astros +120 and Chicago Cubs -142. The over/under is set at 7 runs.

Who is projected to win Houston Astros vs. Chicago Cubs, and what are the win probabilities?

The model projects the Chicago Cubs to win by 0.8 runs. Win probability is 59% for the Chicago Cubs and 41% for the Houston Astros.

Who are the probable starting pitchers for Houston Astros vs. Chicago Cubs?

For this matchup, Houston Astros is expected to start Spencer Arrighetti (RHP; 1.50 ERA), while Chicago Cubs will likely go with Jameson Taillon (RHP; 4.97 ERA). Pitching matchups can change due to injuries, rest days, or strategic decisions.

What are the best bets for Houston Astros vs. Chicago Cubs (run line, moneyline, total)?

The SportsGrid model's top game pick is Total O 7. The projected margin supports this pick.

What are the top player prop picks for Houston Astros vs. Chicago Cubs?

Top player props include Dansby Swanson Over 0.5 RBIs, Carson Kelly Over 0.5 RBIs, Mike Busch Over 0.5 RBIs. These are highlighted as strong value plays by the SportsGrid model.