Astros vs. Cubs Game Preview: Live MLB Prediction, Odds & Picks
🟢•Next update in: 12 minutes from now
Astros vs. Cubs preview (May 22). Updated every 15 minutes with current odds (Cubs -142), Dansby Swanson props & pitching matchup: Spencer Arrighetti vs. Jameson Taillon (probable).
Today's Data Snapshot
| Market Source: | FanDuel |
|---|---|
| Primary Prediction: | Cubs -1.5 |
| Key Player Prop: | Dansby Swanson Over 0.5 RBIs |
| Probable Pitchers: | Spencer Arrighetti (RHP; 1.50 ERA) vs. Jameson Taillon (RHP; 4.97 ERA) |



Houston Astros
20-31
Apple TV+

Chicago Cubs
29-21

GAME PREDICTIONS
PREDICTED GAME OUTCOME
CHANCE TO WIN
59%
Model Picks
Cubs
Cubs -1.5
Total
Total O 7
Insights provided by the SportsGrid betting model
LATEST PLAYER PROPS
LATEST PLAYER PROPS
Frequently Asked Questions
What are the latest odds and run line for Houston Astros vs. Chicago Cubs?
The Chicago Cubs are favored by 1.5 runs on the run line (-1.5), while the Houston Astros are underdogs +1.5 runs. The moneyline is Houston Astros +120 and Chicago Cubs -142. The over/under is set at 7 runs.
Who is projected to win Houston Astros vs. Chicago Cubs, and what are the win probabilities?
The model projects the Chicago Cubs to win by 0.8 runs. Win probability is 59% for the Chicago Cubs and 41% for the Houston Astros.
Who are the probable starting pitchers for Houston Astros vs. Chicago Cubs?
For this matchup, Houston Astros is expected to start Spencer Arrighetti (RHP; 1.50 ERA), while Chicago Cubs will likely go with Jameson Taillon (RHP; 4.97 ERA). Pitching matchups can change due to injuries, rest days, or strategic decisions.
What are the best bets for Houston Astros vs. Chicago Cubs (run line, moneyline, total)?
The SportsGrid model's top game pick is Total O 7. The projected margin supports this pick.
What are the top player prop picks for Houston Astros vs. Chicago Cubs?
Top player props include Dansby Swanson Over 0.5 RBIs, Carson Kelly Over 0.5 RBIs, Mike Busch Over 0.5 RBIs. These are highlighted as strong value plays by the SportsGrid model.





























