TJ Inman

<a href="https://www.sportsgrid.com/ncaaf">College football</a> is back, baby! From now until the start of December, we will be keeping a close eye on all the action, sharing our expert analysis and betting insights every week. Stay up to date with the top picks, predictions, and betting advice for all things college football. 
Check out what bets we&#8217;re targeting for the Week 1 showdown between the LSU Tigers and Clemson Tigers!
<h2><a href="https://www.sportsgrid.com/ncaaf/video/clemson-vs-lsu-key-game-with-playoff-implications">Where to Watch LSU Tigers at Clemson Tigers</a></h2>
<ul>
<li>Stadium: Memorial Stadium</li>
<li>Location: Clemson, South Carolina</li>
<li>Where to Watch: ABC</li>
<li>Time: 7:30 p.m. ET</li>
<li>Spread: Clemson -3.5 | Total: 57.5</li>
<li>Moneyline: Clemson -178 | LSU +146</li>
</ul>
Note: All odds are subject to change after article publication. Get the <a href="https://www.sportsgrid.com/nfl/picks">most up-to-date odds here</a>.
On Saturday night in the Upstate region of South Carolina, a top ten clash between two football powerhouses is set to take place. It&#8217;s a game rife with storylines and intrigue that goes well beyond the meaningless arguments over which school has the &#8220;real Death Valley." This is a critical matchup for both head coaches as opposing philosophies square off. Brian Kelly and LSU have invested heavily in the portal, while Dabo Swinney has famously used it as sparingly as any school in the country (military academies excluded). Clemson badly wants to get a marquee win over an SEC program, and LSU badly wants to break its losing streak in season-openers. It&#8217;s a battle of two quarterbacks who have grown within their respective programs and now carry the burden of expectations as <a href="https://www.sportsgrid.com/cfb/players/cade-klubnik/37193">Cade Klubnik</a> and <a href="https://www.sportsgrid.com/cfb/players/garrett-nussmeier/51357">Garrett Nussmeier</a> open the campaign with legitimate Heisman Trophy chances. It&#8217;s only Week 1, but this game between LSU and Clemson feels like it carries all the importance of a late November showdown.
On the field, both teams expect to be led by their passing attacks. LSU has a very talented group of wide receivers, and Nussmeier has, quite possibly, the best arm in college football. Clemson feels excellent about one safety and one cornerback. Still, there are question marks surrounding the other starting safety position opposite of <a href="https://www.sportsgrid.com/cfb/players/khalil-barnes/37268">Khalil Barnes</a>, and you can bet that LSU will try to test the unproven secondary. On the other side, Klubnik is one of the best dual-threat quarterbacks in the nation, and he plans on shouldering a larger share of the rushing attack this season after the departure of running back Phil Mafah. When Klubnik is aggressive as a runner, Clemson&#8217;s offense is very dangerous. The Clemson Tigers have the best offensive line they&#8217;ve had in a long time, and they might have the best trio of wide receivers in the country. The passing attack of Clemson will attempt to exploit an LSU secondary that has been remade again in the portal. 
Judging by last season&#8217;s statistics, LSU&#8217;s best bet would be to run the ball against a Clemson defense that was near the bottom of the country in stopping the run. Of course, much has changed since last season, and Clemson believes they have addressed that shortcoming with the addition of defensive coordinator Tom Allen. Still, it would be wise for the Bayou Bengals to at least try to test Clemson&#8217;s run defense and see if the Tigers have improved as much as they hope. This game could be decided in the trenches, and LSU is replacing four starters on the offensive line with the one returning starter, possibly splitting time this season. Edge rushers like <a href="https://www.sportsgrid.com/cfb/players/tj-parker/37155">T.J. Parker</a> and <a href="https://www.sportsgrid.com/cfb/players/will-heldt/26452">Will Heldt</a> will try to get after that new line and harass Nussmeier. Meanwhile, Clemson believes this is the best offensive line they&#8217;ve had in a decade.
The SportsGrid model is all over Clemson, laying a five-star pick on the orange and purple Tigers to cover the 3.5-point spread in this Week 1 matchup. There is no recommended play on the total.
<h2>Best Bet: Clemson -3.5</h2>
Matriculate down the field with SportsGrid’s FREE Top<a href="https://www.sportsgrid.com/ncaaf/picks"> College Football Picks</a> and<a href="https://www.sportsgrid.com/ncaaf/player-props"> College Football Player Prop Picks</a> every week!

College Football Best Bets: No. 9 LSU Tigers at No. 4 Clemson Tigers

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The college football season is already underway, and it gets turbo-charged with a loaded Week one slate. Saturday night sees a matchup of top ten Tigers!

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