College Football Week 6: Predicting the Outcomes of Every Top 25 Game

Zack Cook
Host · Writer
No. 8 Miami Hurricanes (-10.5) vs. California Golden Bears
This is a really nice matchup for the Miami Hurricanes to bounce back in. Yes, they picked up the win last week, but they need a big time response in the college football world to remind everyone of their aspirations.
Prediction: Miami 35, Cal 21
Michigan State Spartans vs. No. 6 Oregon Ducks (-24.5)
We're still kind of waiting for the Oregon Ducks to make their mark this season. With their addition into the Big Ten this year, the Ducks aren't afraid to run up the score against the Spartans.
Prediction: Oregon 38, Michigan State 13
Syracuse Orange vs. No. 25 UNLV Rebels (-6.5)
We're expecting some fireworks in this clash between Syracuse and UNLV this week. The Rebels have the talent to pull away late in this matchup and stay ranked.
Prediction: UNLV 33, Syracuse 25
UCLA Bruins vs. No. 7 Penn State Nittany Lions (-27.5)
It's going to be interesting to see how this UCLA team manages in these early starts on the road in the Big Ten. The Nittany Lions continue trucking along in this matchup and win big.
Prediction: Penn State 38, UCLA 10
SMU Mustangs vs. No. 22 Louisville Cardinals (-6.5)
Although there's been moments I've been impressed with SMU, I fully expect the Louisville Cardinals to have a bounce back showing after their loss to Notre Dame and cover the number.
Prediction: Louisville 33, SMU 25
No. 9 Missouri Tigers vs. No. 25 Texas A&M Aggies (-2.5)
A lot of eyeballs will be on this clash between Texas A&M and Missouri in Week 6. With how the Aggies have continued to look on defense, I like for them to cover the number at home.
Prediction: Texas A&M 26, Missouri 21
Iowa Hawkeyes vs. No. 3 Ohio State Buckeyes (-19.5)
Yes, the Iowa Hawkeyes can compete defensively, but they won't be able to say the same offensively against this Ohio State defense. The Buckeyes pull away in the second half and pick up another big win.
Prediction: Ohio State 32, Iowa 6
No. 23 Indiana Hoosiers vs. Northwestern Wildcats
I've been pretty impressed with what I've seen from the Indiana Hoosiers this season. This team needs to be motivated on a weekly basis to keep their ranking, and they continue that streak against Northwestern.
Prediction: Indiana 27, Northwestern 13
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No. 12 Ole Miss Rebels (-9.5) vs. South Carolina Gamecocks
After being upset by Kentucky last week, the Ole Miss Rebels can't afford to take the South Carolina Gamecocks lightly. The Rebels pull away in the second half to get back on track.
Prediction: Ole Miss 30, South Carolina 18
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Auburn Tigers vs. No. 5 Georgia Bulldogs (-24.5)
The Georgia Bulldogs will be looking for a response after a crushing defeat in Week 5 against the Crimson Tide. Although they should win by a sizable margin, it won't be enough to cover the big spread.
Prediction: Georgia 35, Auburn 16
No. 1 Alabama Crimson Tide (-23.5) vs. Vanderbilt Commodores
After an emotional victory in Week 5 over the Georgia Bulldogs at home, it's not difficult to envision the Crimson Tide having a let down performance in Week 6 against the Commodores.
Prediction: Alabama 31, Vanderbilt 17
Utah State Aggies vs. No. 21 Boise State Broncos (-26.5)
With how the Boise State Broncos run the football, Utah State is a program that's in for a world of pain on Saturday. Broncos win big at home.
Prediction: Boise State 47, Utah State 20
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No. 15 Clemson Tigers (-14.5) vs. Florida State Seminoles
The Clemson Tigers have been very good since their opening week loss to the Georgia Bulldogs. It's hard to have any faith in the product that the Seminoles bring to the table on a weekly basis.
Prediction: Clemson 31, Florida State 15
Baylor Bears vs. No. 16 Iowa State Cyclones (-11.5)
The Baylor Bears have continued to give us mixed signals this season. In any case, we're going back to the well in pursue of a game they can cover and keep to within ten points.
Prediction: Iowa State 28, Baylor 20
No. 10 Michigan Wolverines vs. Washington Huskies (-2.5)
This line gave me some real pause when I saw it. The Huskies are slight home favorites in Week 6 against the Wolverines. The underlying numbers suggest that the Huskies can indeed cover the field goal here.
Prediction: Washington 23, Michigan 20
No. 11 USC Trojans (-8.5) vs. Minnesota Golden Gophers
I like this spot a lot for the USC Trojans. The Golden Gophers have been better than many thought this year, but the Trojans is offense is due for an explosive outing.
Prediction: USC 30, Minnesota 20
No. 4 Tennessee Volunteers vs. Arkansas Razorbacks
I was expecting this line to be much bigger, and that gives me some pause here. Arkansas has quietly been a competitive team, and should give the Volunteers a punch to the mouth here.
Prediction: Tennessee 31, Arkansas 21
No. 8 Miami Hurricanes (-10.5) vs. California Golden Bears
This is a really nice matchup for the Miami Hurricanes to bounce back in. Yes, they picked up the win last week, but they need a big time response in the college football world to remind everyone of their aspirations.
Prediction: Miami 35, Cal 21
Michigan State Spartans vs. No. 6 Oregon Ducks (-24.5)
We're still kind of waiting for the Oregon Ducks to make their mark this season. With their addition into the Big Ten this year, the Ducks aren't afraid to run up the score against the Spartans.
Prediction: Oregon 38, Michigan State 13
