Bills vs. Jets MNF Week 6 Prediction | NFL Picks Today, Best Bets

The Buffalo Bills started the season off strong, but after back-to-back losses, Buffalo sits at 3-2 with a big-time matchup on Monday Night Football. On the flip side, the New York Jets enter with a 2-3 record and an interim head coach after firing Robert Saleh to start the week. With a chance for the Bills to add to their lead atop the AFC East, or the Jets to tie Buffalo atop the division, this game has the makings for a dogfight.

Bills vs. Jets Game Info, Where to Watch and Odds

• Location: MetLife Stadium (Rutherford, New Jersey) | Time: 8:15 PM ET 
• Where to Watch: ESPN/ABC
• Spread: Bills -1.5, Moneyline: Bills -116, Total: 40.5

Bills vs. Jets Best Bet: Jets +1.5

The Jets enter this matchup with a chance to put themselves right back at the top of the division. After an inconsistent start, the team moved on from their head coach, hoping to find a winning recipe before the season was lost. On their home field, they’ll have a chance to prove they have the talent to make a deep postseason run. The Jets get back in the win column on Monday night.

Full Bills-Jets Analysis Below

Bills vs. Jets Best Total Bet: Over 40.5

Divisional battles often lead to ugly games, with each team playing one another twice a year. This season, the first matchup between the Jets and Bills may be a bit different. Buffalo has a new-look offense, while the Jets finally have the chance to compete with Aaron Rodgers in the mix. A final score of 27-23 is a realistic outcome for this divisional showdown.

Bills Best Player Bet: James Cook Any Time Touchdown +115

James Cook has been a consistent playmaker for the Bills offense this season. The versatile running back is up to 434 total yards and five touchdowns on the season. With his ability to catch out of the backfield while being a shifty runner, Cook often finds himself in a position to score. And against a Jets defense that allows opposing offenses to rush for 119.2 yards per game, the Georgia product could be in line for a monster night.

Jets Best Player Bet: Garrett Wilson Any Time Touchdown +175

Garrett Wilson has been a standout receiver since the Jets drafted him in 2022. Even through lackluster quarterback play, the Ohio State alum has shined. Now, his connection with Rodgers is growing and he looks poised for a big-time game soon. Fresh off 13 receptions (23 targets), 101 yards, and one touchdown against the Vikings last week, Wilson has the chance to build on his impressive performance from last week.