49ers vs. Cowboys Preview: Picks, Odds and Analysis

Segment Spotlight: Quick Hits From NFL Pro Football Today

49ers Favored to Flex Their Muscle Against the Cowboys in Dallas

The 49ers head to Dallas looking to improve to 8-1. Despite dealing with injuries, they remain the class of the NFC and have added Keenan Allen to bolster the offense.

The Cowboys are home underdogs, catching 4.5 points. That line appears justified based on how much better San Francisco has performed against its schedule. Brock Purdy will also look to continue building his MVP case, with his odds currently among the top three alongside Josh Allen and Trevor Lawrence.

If the 49ers flex their muscle in this matchup, it will be difficult to make a strong case for another team coming out of the NFC. Dallas has been difficult to trust in 2026, while San Francisco looks like the better team on both sides of the ball.

How quickly Allen contributes remains to be seen. He is a veteran, but joining a new situation and playing during the same week is difficult. His workload is uncertain, while Jordan Watkins could continue to earn opportunities in the offense. DeMarcus Robinson should also be involved.

Dallas continues to struggle defensively, even with players healthy and on the field. San Francisco is the preferred side, although there are still concerns about how the age of its roster could affect a deep playoff run in December and January.

The total of 55.5 points is also notable because it suggests the Cowboys could remain competitive. If the game follows San Francisco’s ideal plan, the 49ers should control the pace and keep Dallas from scoring more than 24 points.

The betting angles could correlate: those who favor the over may also want to consider Dallas covering the 4.5-point spread, while those who prefer the under may want to consider laying the points with San Francisco.