NCAA Tournament Bracket Busters: Ranking the Most Likely Upsets for Friday

16) East Region First Round: (16) Mt. St. Mary's Over Duke (1)

(16) Mt. St. Mary's (23-12) vs (1) Duke (31-3)

WHERE TO WATCH & bet365 ODDS

Arena: Lenovo Center

Location: Raleigh, NC

Date: Friday, March 21

Where to Watch: CBS

Time: 2:50 p.m. ET

Spread: Duke -32 | Total: 140.5

Moneyline: Duke -20000 | Mt. St. Mary's +2800 

PICK BASED ON ESPN'S BPI

(1) Duke (1st BPI) Over (16) American (227th BPI)

PICK BASED ON KenPom

(1) Duke (1st KenPom) Over (16) American (238th KenPom)

2) West Region First Round: (12) Colorado State Over Memphis (5)

(12) Colorado State (25-9) vs (5) Memphis (29-5)

WHERE TO WATCH & bet365 ODDS

Arena: Climate Pledge Arena

Location: Seattle, WA

Date: Friday, March 21

Where to Watch: TBS

Time: 2:00 p.m. ET

Spread: Colorado State -2.5 | Total: 147.5

Moneyline: Colorado State -140 | Memphis +120

PICK BASED ON ESPN'S BPI

(5) Memphis (46th BPI) Over (12) Colorado State (53rd BPI)

PICK BASED ON KenPom

(12) Colorado State (44th KenPom) Over (5) Memphis (49th KenPom)

3) South Region First Round: (11) North Carolina Over Ole Miss (6)

(11) North Carolina (22-13) vs (6) Ole Miss (22-11)

WHERE TO WATCH & bet365 ODDS

Arena: Fiserv Forum

Location: Milwaukee, Wisconsin

Date: Friday, March 21

Where to Watch: TNT

Time: 4:05 p.m. ET

Spread: North Carolina -1.5 | Total: 155.5

Moneyline: North Carolina -125 | Ole Miss +105

PICK BASED ON ESPN'S BPI

(11) North Carolina (25th BPI) Over (6) Ole Miss (32nd BPI)

PICK BASED ON KenPom

(6) Ole Miss (27th KenPom) Over (11) North Carolina (30th KenPom)

4) East Region First Round: (10) Vanderbilt Over Saint Mary’s (7)

(10) Vanderbilt (20-12) vs (7) Saint Mary’s (28-5)

WHERE TO WATCH & bet365 ODDS

Arena: Rocket Arena

Location: Cleveland, OH

Date: Friday, March 21

Where to Watch: CBS

Time: 3:15 p.m. ET

Spread: Saint Mary’s -4.0 | Total: 136.5

Moneyline: Saint Mary’s -180 | Vanderbilt +150

PICK BASED ON ESPN'S BPI

(7) Saint Mary’s (30th BPI) Over (10) Vanderbilt (56th BPI)

PICK BASED ON KenPom

(7) Saint Mary's (20th KenPom) Over (10) Vanderbilt (48th KenPom)

5) South Region First Round: (10) New Mexico Over Marquette (7)

(10) New Mexico (19-15) vs (7) Marquette (23-10)

WHERE TO WATCH & bet365 ODDS

Arena: Rocket Arena

Location: Cleveland, OH

Date: Friday, March 21

Where to Watch: TBS

Time: 7:25 p.m. ET

Spread: Marquette -4 | Total: 152.0

Moneyline: Marquette -170 | New Mexico +145

PICK BASED ON ESPN'S BPI

(7) Marquette (20th BPI) Over (10) New Mexico (49th BPI)

PICK BASED ON KenPom

(7) Marquette (26th KenPom) Over New Mexico (42nd KenPom)

6) West Region First Round: (9) Oklahoma Over UConn (8)

(9) Oklahoma (20-13) vs (1) UConn (23-10)

WHERE TO WATCH & bet365 ODDS

Arena: Lenovo Center

Location: Raleigh, NC

Date: Friday, March 21

Where to Watch: TNT

Time: 9:25 p.m. ET

Spread: UConn -4.5 | Total: 148.5

Moneyline: UConn -200 | Oklahoma +165

PICK BASED ON ESPN'S BPI

(8) UConn (16th BPI) Over (9) Oklahoma (43rd BPI)

PICK BASED ON KenPom

(8) UConn (35th KenPom) Over (9) Oklahoma (40th KenPom)

7) West Region First Round: (13) Grand Canyon Over Maryland (4)

(13) Grand Canyon (26-7) vs (4) Maryland (25-8)

WHERE TO WATCH & bet365 ODDS

Arena: Climate Pledge Arena

Location: Seattle, WA

Date: Friday, March 21

Where to Watch: TBS

Time: 4:35 p.m. ET

Spread: Maryland -10.5 | Total: 150.0

Moneyline: Maryland -575 | Grand Canyon +425

PICK BASED ON ESPN'S BPI

(4) Maryland (13th BPI) Over (13) Grand Canyon (87th BPI)

PICK BASED ON KenPom

(4) Maryland (12th KenPom) Over (13) Grand Canyon (95th KenPom)

8) Midwest Region First Round: (11) Xavier Over Illinois (6)

(11) Xavier (22-11) vs (6) Illinois (21-12)

WHERE TO WATCH & bet365 ODDS

Arena: Fiserv Forum

Location: Milwaukee, WI

Date: Friday, March 21

Where to Watch: CBS

Time: 9:45 p.m. ET

Spread: Illinois -3.5 | Total: 161.0

Moneyline: Illinois -165 | Xavier +140

PICK BASED ON ESPN'S BPI

(6) Illinois (23rd BPI) Over (11) Xavier (37th BPI)

PICK BASED ON KenPom

(6) Illinois (18th KenPom) Over (11) Xavier (41st KenPom)

9) East Region First Round: (12) Liberty Over Oregon (5)

(12) Liberty (28-6) vs (5) Oregon (24-9)

WHERE TO WATCH & bet365 ODDS

Arena: Climate Pledge Arena

Location: Seattle, WA

Date: Friday, March 21

Where to Watch: truTV

Time: 10:10 p.m. ET

Spread: Oregon -6.5 | Total: 139.5

Moneyline: Liberty +235 | Oregon -290

PICK BASED ON ESPN'S BPI

(5) Oregon (36th BPI) Over (12) Liberty (85th BPI)

PICK BASED ON KenPom

(5) Oregon (31st KenPom) Over (12) Liberty (60th KenPom)

10) East Region First Round: (13) Akron Over Arizona (4)

(13) Akron (28-6) vs (4) Arizona (22-12)

WHERE TO WATCH & bet365 ODDS

Arena: Climate Pledge Arena

Location: Seattle, WA

Date: Friday, March 21

Where to Watch: CBS

Time: 7:35 p.m. ET

Spread: Arizona -14.0 | Total: 167.0

Moneyline: Arizona -1100 | Akron +700

PICK BASED ON ESPN'S BPI

(4) Arizona (9th BPI) Over (13) Akron (112th BPI)

PICK BASED ON KenPom

(4) Arizona (14th KenPom) Over (13) Akron (96th KenPom)

11) South Region First Round: (14) Lipscomb Over Iowa State (3)

(14) Lipscomb (25-9) vs (3) Iowa State (24-9)

WHERE TO WATCH & bet365 ODDS

Arena: Fiserv Forum

Location: Milwaukee, Wisconsin

Date: Friday, March 21

Where to Watch: TNT

Time: 1:30 p.m. ET

Spread: Iowa State -14 | Total: 143.0

Moneyline: Iowa State -1300 | Lipscomb +800

PICK BASED ON ESPN'S BPI

(3) Iowa State (7th BPI) Over (14) Lipscomb (106th BPI)

PICK BASED ON KenPom

(3) Iowa State (11th KenPom) Over (14) Lipscomb (82nd KenPom)

12) Midwest Region First Round: (14) Troy Over Kentucky (3)

(14) Troy (23-10) vs (6) Kentucky (22-11)

WHERE TO WATCH & bet365 ODDS

Arena: Fiserv Forum

Location: Milwaukee, WI

Date: Friday, March 21

Where to Watch: CBS

Time: 7:10 p.m. ET

Spread: Kentucky -11 | Total: 153.5

Moneyline: Kentucky -650 | Troy +475

PICK BASED ON ESPN'S BPI

(3) Kentucky (17th BPI) Over (14) Troy (109th BPI)

PICK BASED ON KenPom

(3) Kentucky (16th KenPom) Over (14) Troy (94th KenPom)

13) South Region First Round: (15) Bryant Over Michigan State (2)

(15) Bryant (23-11) vs (1) Michigan State (27-6)

WHERE TO WATCH & bet365 ODDS

Arena: Rocket Arena

Location: Cleveland, OH

Date: Friday, March 21

Where to Watch: TBS

Time: 10:00 p.m. ET

Spread: Michigan State -17.5 | Total: 152.5

Moneyline: Michigan State -2500 | +1250

PICK BASED ON ESPN'S BPI

(2) Michigan State (11th BPI) Over (15) Bryant (131st BPI)

PICK BASED ON KenPom

(2) Michigan State (8th KenPom) Over (15) Bryant (147th KenPom)

14) East Region First Round: (15) Robert Morris Over Alabama (2)

(15) Robert Morris (26-8) vs (2) Alabama (25-8)

WHERE TO WATCH & bet365 ODDS

Arena: Rocket Arena

Location: Cleveland, OH

Date: Friday, March 21

Where to Watch: truTV

Time: 12:40 p.m. ET

Spread: Alabama -22.5 | Total: 165.5

Moneyline: Alabama -8000 | Robert Morris +1800

PICK BASED ON ESPN'S BPI

(2) Alabama (6th BPI) Over (16) Robert Morris (168th BPI)

PICK BASED ON KenPom

(2) Alabama (6th KenPom) Over (16) Robert Morris (139th KenPom)

15) West Region First Round: (16) Norfolk State vs. Florida (1)

(16) Norfolk State (24-10) vs (1) Florida (30-4)

WHERE TO WATCH & bet365 ODDS

Arena: Lenovo Center

Location: Raleigh, NC

Date: Friday, March 21

Where to Watch: TNT

Time: 6:50 p.m. ET

Spread: Florida -28.5 | Total: 153.5

Moneyline: Florida -10000 | Norfolk State +2500

PICK BASED ON ESPN'S BPI

(1) Florida (4th BPI) Over (16) Norfolk State (171st BPI)

PICK BASED ON KenPom

(1) Florida (2nd KenPom) Over (16) Norfolk State (179th KenPom)

16) East Region First Round: (16) Mt. St. Mary's Over Duke (1)

(16) Mt. St. Mary's (23-12) vs (1) Duke (31-3)

WHERE TO WATCH & bet365 ODDS

Arena: Lenovo Center

Location: Raleigh, NC

Date: Friday, March 21

Where to Watch: CBS

Time: 2:50 p.m. ET

Spread: Duke -32 | Total: 140.5

Moneyline: Duke -20000 | Mt. St. Mary's +2800 

PICK BASED ON ESPN'S BPI

(1) Duke (1st BPI) Over (16) American (227th BPI)

PICK BASED ON KenPom

(1) Duke (1st KenPom) Over (16) American (238th KenPom)