Louisville vs. Notre Dame Week 5 Prediction | College Football Picks Today | Best Bets

Entering Week 5, Notre Dame and Louisville clash for yet another showdown between ranked teams. The Cardinals look to continue their undefeated season while the Fighting Irish look to prove their loss early in the season was a fluke.

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Louisville vs. Notre Dame Game Info and Odds

Location: Notre Dame Stadium | Time: 3:30 p.m. ET | Where to Watch: Peacock
Spread: Notre Dame -6.5, Moneyline: Notre Dame -215, Total: 47.5

Louisville vs. Notre Dame Best Bet: Louisville +176

Both squads enter a fairly even matchup between the No. 15 ranked Cardinals and No. 16 ranked Fighting Irish. The game could go either way, but with Notre Dame struggling to find consistency in the passing game, the team can only survive so long. Louisville has a bit more well-rounded offense that could score just enough points to outlast Marcus Freeman’s squad in the ACC duel. 

Louisville vs. Notre Dame Best Total Bet: Under 47.5

This game could lean to be a battle of the defenses. With both offenses potentially struggling, Louisville could win with a final score of 23-17.

Louisville Best Player Bet: Ja’Corey Brooks Any Time Touchdown +170

The Cardinals have found success through the air through the season’s first few weeks. Louisville’s wide receiver Ja’Corey Brooks has been a large reason for the team’s successful passing game. The senior is up to 297 receiving yards and two touchdowns on the year. Brooks could add to his season stats by finding the endzone against Notre Dame.

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Notre Dame Best Player Bet: Jeremiyah Love First Touchdown Scorer +400

Jeremiyah Love has been on an absolute tear this season for the Fighting Irish. The running back has tallied up 339 rushing yards on 46 carries, averaging 7.4 yards per carry. With only four touchdowns on the season, the sophomore could be destined to get into the end zone against the Cardinals.

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