Ole Miss vs South Carolina Week 6 Prediction | College Football Picks Today, Best Bets

Ole Miss heads to South Carolina for a big-time SEC showdown against the Gamecocks. With the Rebels sitting at 3-1, they could be in the danger zone of missing out on the College Football Playoffs if they drop another game. Meanwhile, Shane Beamer’s squad is fresh off a bye week, looking to make a statement with a win to improve to 4-1.

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Ole Miss vs South Carolina

Location: Williams-Brice Stadium (Columbia, SC) | Time: 3:30 PM ET | Where to Watch: ESPN

Spread: Ole Miss -9.5, Moneyline: Ole Miss -315, Total: 53.5

Ole Miss vs South Carolina Best Bet: South Carolina ML +250

The Gamecocks have continuously shocked the nation so far this season. The team was a LaNorris Sellers injury and a couple of unfavorable and questionable penalties away from upsetting LSU and being 4-0. With the home crowd’s energy and Sellers’s return, South Carolina could be poised to upset Ole Miss for the second week straight.

Ole Miss vs South Carolina Best Total Bet: Over 53.5

Ole Miss and South Carolina have an offense that can score quickly. The Rebels average 47.4 points per game, while the Gamecocks trail just behind with 34.3 points per game. As both teams hope to make a statement on Saturday, this game could be a shootout that ends with a final score of 34-30.

Ole Miss Best Player Bet: Antwane Wells Jr. Any Time Touchdown +175

Antwane Wells Jr. is set to return to South Carolina after transferring from the Gamecocks in the offseason. The wide receiver left unexpectedly, leaving a bad taste in the mouths of USC players and their fans. That said, the growing bad blood between Wells and his former team had all the makings of a heated game. In his return, it wouldn’t be a surprise to see Wells and head coach Lane Kiffin emphasize getting the talented pass catcher in the endzone.

South Carolina Best Bet: LaNorris Sellers Any Time Touchdown +130

LaNorris Sellers has been one of the best players for South Carolina so far this season. The freshman quarterback has taken strides each week and was on his way to a career game before getting injured in the first half against LSU. After two weeks off, the dual-threat QB is set to make his return versus Ole Miss on Saturday. With his legs being a big part of the team’s offense, Sellers could end the day with more than one rushing touchdown.