#2 Novak Djokovic vs. #6 Andrey Rublev
As Novak Djokovic embarks on his quest for a fifth U.S. Open and 25th career slam, Andrey Rublev is simply looking to reach his first semifinal at a grand slam in his career. The Russian has a lone victory out of six tries over Joker, which came in the Belgrade Final in 2022 on clay. With four defeats to the Serbian on hard surfaces, it'll be a tall task for him to pull off the upset to reach that coveted semifinal.
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