2025 NFL Schedule: Key Matchups That Will Decide Each Division

NFC West

Week 10: Los Angeles Rams vs. San Francisco 49ers

By Week 10, the San Francisco 49ers will be playing their fourth divisional contest. At the same time, it will be just the second intra-divisional game for the Los Angeles Rams, with both of those coming against the 49ers. If either team can claim both contests, they will be well on their way to securing the division title.

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AFC East

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Week 10: Buffalo Bills vs. Miami Dolphins

The Buffalo Bills are light years ahead of the rest of the AFC East. A Week 10 contest against the Miami Dolphins will be their most sincere challenge, and Buffalo will be well on its way to securing the AFC East.

AFC South

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Week 13: Houston Texans vs. Indianapolis Colts

NFL schedule makers knew exactly what they were doing when they scheduled the Houston Texans and Indianapolis Colts in Week 18. However, the division will be locked up well before then. The Texans will use a Week 13 clash to solidify their grip on the AFC South and never look back.

AFC West

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Week 15: Los Angeles Chargers vs. Kansas City Chiefs

The Kansas City Chiefs' grip on the AFC West is loosening, and the Los Angeles Chargers could be ready to pry it away. These teams meet in Week 1 and then again in Week 15, which will be the catalyst in deciding which side claims dominion over this division.

NFC North

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Week 13: Green Bay Packers vs. Detroit Lions

Last season, the Detroit Lions needed all 17 games to clinch the NFC North. While they won't have it locked up in Week 13, the Lions will be able to use that showdown versus the Green Bay Packers to tighten their lead atop the division standings.

NFC East

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Week 18: Washington Commanders vs. Philadelphia Eagles

Another prime example of just how crafty the NFL can be when it comes to scheduling. The Philadelphia Eagles and Washington Commanders are the frontrunners in the NFC East. They also don't meet until Week 16. Still, the NFC East winner likely won't be decided until these division foes meet again in Week 18.

NFC South

Week 15: Atlanta Falcons vs. Tampa Bay Buccaneers

This is the last time the Atlanta Falcons are getting the benefit of the doubt, but big things are expected from the NFC South contenders in 2025. They can use a Week 15 clash versus the Tampa Bay Buccaneers to upset the balance of the division.

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NFC West

Week 10: Los Angeles Rams vs. San Francisco 49ers

By Week 10, the San Francisco 49ers will be playing their fourth divisional contest. At the same time, it will be just the second intra-divisional game for the Los Angeles Rams, with both of those coming against the 49ers. If either team can claim both contests, they will be well on their way to securing the division title.

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