NFL · 6 months ago

2025 NFL Schedule Release: 10 Best Quarterback Matchups Ranked

TJ Inman

Host · Writer

10. Dallas Cowboys vs. Arizona Cardinals
The final game on the list again eschews Dallas’ matchups with Jalen Hurts or Jayden Daniels. It spotlights another quarterback hoping for a season that elevates his status: Arizona’s Kyler Murray. Murray is now a full year removed from knee surgery and has publicly said he is ready to return to running the ball more often. If that is the case and his mobility is entirely back, the Cardinals have enough pieces around him to be an exciting team in the NFC West. Murray has the talent to push the Rams and 49ers in the West, and a matchup with the Cowboys is a chance to showcase it. The Cowboys host the Cardinals on Monday Night Football on November 3.

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1. Buffalo Bills vs. Kansas City Chiefs
The premier quarterback rivalry in the NFL will be renewed again during the 2025-2026 season as Patrick Mahomes and the Kansas City Chiefs take on Josh Allen and the Buffalo Bills on November 2 in Orchard Park, NY. The triumvirate of Mahomes, Allen, and Ravens quarterback Lamar Jackson is broadly considered the top three signal-callers in the league right now, and that has been stamped repeatedly with playoff clashes nearly every season between those three teams. Allen has done basically everything asked of him in his career, except getting past Mahomes and the Chiefs in the playoffs. This game usually impacts home-field advantage for the AFC Championship Game.

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2. Kansas City Chiefs vs. Baltimore Ravens
The Baltimore Ravens got more dangerous ahead of last season as they added Derrick Henry to the offense and gave Lamar Jackson some additional help in the running game. Jackson took his game up another notch and is now squarely in the mix for the game’s Most Valuable Player award annually. That means the September 28 showdown between Jackson’s Ravens and Patrick Mahomes’s Kansas City Chiefs will be, once again, a contest between two elite quarterbacks and two of the top teams in the NFL with playoff seeding implications.
3. Washington Commanders vs. Philadelphia Eagles
The Philadelphia Eagles are the reigning Super Bowl Champions and rule the NFC East. Jalen Hurts has continued to progress and prove doubters wrong as he keeps winning games. The Washington Commanders enter the 2025 season with as much hope as that franchise has had in decades, and they are coming for the East crown. Jayden Daniels had a fantastic rookie campaign, leading the Commanders to the playoffs and immediately inserting himself into the conversation for best young quarterback in the sport. These two play on December 20 and January 3/4, and those two games will likely go a long way towards deciding the NFC East and home-field advantage in the playoffs.
4. Cincinnati Bengals vs. Baltimore Ravens
It is easy to forget Joe Burrow within the cluster of AFC quarterbacks. Still, when healthy, the Cincinnati Bengals' slinger is a top-five player at the position, and the Bengals locked up his top two targets this offseason. Burrow can put the Bengals into the mix for the AFC North title, but the two matchups with rival Baltimore and Lamar Jackson will be critical. The Bengals and Ravens will meet twice in three weeks on November 27 (Thursday) and December 14 this season.
5. Baltimore Ravens at Buffalo Bills
The final matchup of the AFC quarterback power triangle is between the Buffalo Bills and the Baltimore Ravens. The two sides have met in the playoffs, and both Lamar Jackson and Josh Allen feel like now is the time to finally vanquish the dragon that is Patrick Mahomes. The Bills and Ravens both figure to be in the mix to win the number one seed in the AFC, and the matchup on September 7 will be pivotal. That's quite a way to kick off the 2025 season!
6. Kansas City Chiefs vs. Washington Commanders
The current top quarterback in the league, Patrick Mahomes, meets the most exciting young quarterback in the NFL, Jayden Daniels, on Monday Night Football on October 27. The Kansas City Chiefs and Washington Commanders did not play last season, so Mahomes and Daniels have yet to face off in the NFL. The two are unlikely to play each other very often, so this is one to savor.
7. Chicago Bears vs. Green Bay Packers
Rivalry games are fantastic, and few rivalries surpass the hatred between the fan bases of the Chicago Bears and the Green Bay Packers. Add the element of both franchises having young quarterbacks hoping to establish themselves, and you have a recipe for a pair of fantastic games to watch. Caleb Williams had a rocky rookie season, but the Bears have given him an exciting young head coach and a bevy of weapons to work with. Jordan Love’s 2024 season was cut short by injuries, but the Packers finally invested in a first-round wide receiver, and there is hope he can take a leap forward in 2025. The two sides play on December 7 and December 20.
8. Dallas Cowboys vs. Los Angeles Chargers
Dak Prescott takes a ton of flak, mainly for his contract and lack of winning in the playoffs. That’s understandable, but he is still the Dallas Cowboys' quarterback, making him a key figure in the NFL. The Cowboys have critical NFC East games, but a matchup in Dallas against seldom-played foe Los Angeles Chargers is intriguing. Can Justin Herbert take the next step in his development under Jim Harbaugh? The Chargers have invested in more weapons on the offensive side of the ball and are counting on Herbert to get the team to the playoffs for the second straight season. A game in Dallas on December 21 could be critical for both teams.
9. New England Patriots vs. Tennessee Titans
The New England Patriots versus the Tennessee Titans on October 19 seems like a pedestrian affair. That might be the case, and both teams might be dreadful. This will be the first clash between rookie Cam Ward and second-year quarterback Drake Maye, and those two will be jockeying for position as they hope to join the list of the elite quarterbacks in the AFC.
10. Dallas Cowboys vs. Arizona Cardinals
The final game on the list again eschews Dallas’ matchups with Jalen Hurts or Jayden Daniels. It spotlights another quarterback hoping for a season that elevates his status: Arizona’s Kyler Murray. Murray is now a full year removed from knee surgery and has publicly said he is ready to return to running the ball more often. If that is the case and his mobility is entirely back, the Cardinals have enough pieces around him to be an exciting team in the NFC West. Murray has the talent to push the Rams and 49ers in the West, and a matchup with the Cowboys is a chance to showcase it. The Cowboys host the Cardinals on Monday Night Football on November 3.

Stay ahead of the game and elevate your sports betting experience with SportsGrid.
1. Buffalo Bills vs. Kansas City Chiefs
The premier quarterback rivalry in the NFL will be renewed again during the 2025-2026 season as Patrick Mahomes and the Kansas City Chiefs take on Josh Allen and the Buffalo Bills on November 2 in Orchard Park, NY. The triumvirate of Mahomes, Allen, and Ravens quarterback Lamar Jackson is broadly considered the top three signal-callers in the league right now, and that has been stamped repeatedly with playoff clashes nearly every season between those three teams. Allen has done basically everything asked of him in his career, except getting past Mahomes and the Chiefs in the playoffs. This game usually impacts home-field advantage for the AFC Championship Game.

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2025 NFL Schedule Release: 10 Best Quarterback Matchups Ranked

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