49ers vs Bills SNF: 6 Favorite NFL Anytime Touchdown Best Bets

Ben DiGiacomo
Host · Writer

We have an exciting Sunday Night Football matchup set featuring the San Francisco 49ers and Buffalo Bills, so we put together our top touchdown props for the action.
How to Approach Christian McCaffrey (-125)
Christian McCaffrey was football’s most potent touchdown scorer last season, as he combined for 21 touchdowns, but he’s failed to do so thus far this season. Getting him at -125 to find the endzone this week is a price we’ve never seen before since he became a member of the 49ers, so it almost feels like we need to bet on him alone. This guy is beyond due to find the endzone, and he surely will see more than enough volume to make backing him worth it.
James Cook (-110)
James Cook has found the endzone in seven of ten games this season for a total of eleven touchdowns. To keep this simple, we don’t believe that the 49ers defense certainly isn’t what it once was, and we just saw Josh Jacobs run for three touchdowns against this defense last Sunday in what will be similar weather conditions. At -110, you must find a way to get this into your betting card.
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Must Bet: George Kittle (+250)
At +250, you just have to find a way to get some action on George Kittle to find the endzone. There are no excuses not to. He’s scored eight touchdowns across the past eight games, emerging as the 49ers’ top red zone threat through the air. This dude is an absolute machine, and the fact that we’re getting him at this price, regardless of the conditions, is too good to pass up.
Worth the Price? Josh Allen (+110)
Josh Allen is looking to top off a great week after getting engaged during the bye with a win on Sunday Night Football, but is he worth backing to score? He’s always a threat to find the endzone with his legs, but if I’m honest, I struggle to find the value. At +110, he’s only scored three times with his legs since Week 2, but he has scored in the past two games. Still, by the numbers, James Cook is a significantly better player to back to score as he’s scored eleven times overall this season, and we’re getting him at -105. If I had to choose -105 for Cook or +110 for Allen, Cook is the smarter bet. However, if you want to build out a same-game touchdown parlay, Allen is worth considering there alongside Cook.
Fade: Deebo Samuel (+220)
I don’t want to say that Deebo Samuel is washed, but he’s been horrible this year. We’re getting him at +220 to find the endzone tonight, but there is still no value to be had with this guy. His target volume is down, he looks slower, and he’s no longer a significant threat to run the ball out of the backfield. Jauan Jennings looks to be this team’s WR1 so he’s worth a ton of value to score a touchdown at +350, or even rookie Ricky Pearsall at +650. This is all to say that Deebo very well could find the endzone, but that doesn’t mean it would be a smart bet.
Bills’ Receiver Roulette: Where is the Value?
When looking at which Bills’ wide receiver is best to back, the honest answer may be none of them. There is far too much variance with these guys, and there is no true red-zone threat for us to look at. In terms of sheer volume, though, Khalil Shakir would have to be the play at +200, given that he’s averaged over seven catches per game across the past five weeks. However, despite recording five red-zone receptions over that stretch, he doesn’t have a touchdown to show for it. Keon Coleman and Amari Cooper are priced slightly less at +190, but I don’t think I’d back either of those over Shakir based on target upside, although Cooper feels due for a breakout. Curtis Samuel at +500 and Mack Hollins at +550 could be worth a small sprinkle to find the endzone, but overall, Shakir is certainly the smartest bet to make here at +200.
All Odds Courtesy of FanDuel Sportsbook

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