49ers vs. Seahawks TNF Week 6 Predictions | NFL Picks Today, Best Bets

The San Francisco 49ers and Seattle Seahawks bring their bad blood to prime time for what could be one of the weekend’s best matchups. The division rivalry alone always makes for a good game. Moreover, the top spot in the NFC West on the line raises the stakes a bit more.

49ers vs. Seahawks: Where to Watch

Location: Lumen Field (Seattle, Washington) | Time: 8:15 PM ET | Where to Watch: Amazon Prime Video

49ers vs. Seahawks Betting Odds

Spread: 49ers -3.5, Moneyline: 49ers -176, Total: 48.5

49ers vs. Seahawks Best Bet: Seahawks ML +148

The Seahawks enter this game as underdogs on their home field. At 3-2, Seattle sits atop their division while the 2-3 Niners look to knock off Mike Macdonald’s squad. In a home game with the importance of a divisional battle, the Seahawks won’t take this matchup lightly. And as San Francisco continues to struggle, there’s no better time than now for Seattle to take care of their biggest divisional threat.

49ers vs. Seahawks Best Total Bet: Over 48.5

Both squads have the firepower to quickly score points and a defense that can slow down a high-powered offense. The problem is that neither team can consistently perform on both sides of the ball. That said, the Thursday Night battle could be an offensive performance, with both squads struggling to slow down the other. A final score of 27-24 is a realistic result.

49ers Best Player Bet: Jordan Mason First Touchdown Scorer +400

Since stepping up in Christian McCaffrey’s absence, Jordan Mason has looked the part. The running back is up to 536 rushing yards and three touchdowns on the year. With the Seahawks stacked secondary, Kyle Shanahan’s squad is striving to get Mason going early. If the Georgia Tech product can put his impact on the game early, it’ll open up opportunities for the offense. Whether it’s a red zone carry or a breakaway run, Mason has an excellent shot to be the first player in the endzone.

Seahawks Best Player Bet: DK Metcalf Any Time Touchdown +145

The Seahawks have seemed to emphasize getting DK Metcalf more involved on offense. Metcalf has 28 receptions, 421 receiving yards, and two touchdowns on the season so far. With his involvement on offense, he seems poised to find the endzone more as the season continues. And there’s no better time than a divisional battle to get their top offensive threat in the endzone.