Chiefs vs 49ers Week 7 Predictions | NFL Picks Today, Best Bets

The Kansas City Chiefs head on the road for a Super Bowl rematch against the San Francisco 49ers. The Chiefs look to continue their undefeated season, while the Niners hope to get over the .500 mark after a rough start.

Chiefs vs 49ers

• Location: Levi’s Stadium (Santa Clara, California) | Time: 4:25 PM ET
• Where to Watch: FOX
• Spread: 49ers -1.5, Moneyline: 49ers -126, Total: 47.5

Chiefs vs 49ers Best Bet: Chiefs ML +108

The Chiefs have been red hot to start this season, and despite injuries, Andy Reid’s squad continues to find a way to win. The Niners have matched up with Kansas City on multiple occasions, and in the last five matchups, the Chiefs are 4-1. With bad blood between both teams, Sunday’s matchup will be a dogfight, but it’s hard to bet against Patrick Mahomes in a big game. 

Chiefs vs 49ers Best Total Bet: Over 47.5

The Chiefs and 49ers both have an offense that can score quickly while also having a defense built to slow down high-powered offenses. In the last two matchups, the average total points scored was 57. That said, a final score of 34-31 seems realistic.

Chiefs Best Player Bet: Travis Kelce Any Time Touchdown +165

Travis Kelce hasn’t been as effective this season as he has been in years prior, but the talented tight end can be depended on to show up when he’s needed most. Kelce hasn’t found the endzone once this year, but in a matchup against the 49ers, there’s no better time than now for the pass-catcher to grab his first score of the year. With Mahomes and Kelce’s chemistry always one to bank on, there’s a solid shot the Cincinnati product finds himself in the endzone at some point before the game ends.

49ers Best Player Bet: Deebo Samuel Any Time Touchdown +105

Deebo Samuel may be one of the most versatile and utilized offensive weapons in the league. The South Carolina alum has already found the endzone twice this season, and like Kelce, he shows up for the big moments. Looking to add to his 117-yard, one-touchdown outing last weekend, Samuel may find himself in the endzone again.

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