Lions vs 49ers MNF Week 17 Predictions | NFL Picks Today, Best Bets

The Detroit Lions are set for an NFC showdown with the San Francisco 49ers on Monday Night Football. Rewind to last season, when this matchup took place in the NFC Championship Game, and where the Niners survived Dan Campbell’s Lions to advance to the Super Bowl. However, only Detroit has managed to stay on top of the league this season.

At 13-2, the Lions can clinch the No. 1 seed in the conference with a win next weekend against the Minnesota Vikings. Meanwhile, San Francisco sits at 6-9, eliminated from the postseason, with nothing but draft positioning riding on their final two games. Nonetheless, in a rematch, both teams could leave it all on the field, primarily for bragging rights.

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Lions vs 49ers

• Location: Levi’s Stadium (Santa Clara, California) | Time: 8:15 p.m. ET
• Where to Watch: ESPN/ABC/ESPN+
• Spread: Lions -3.5, Moneyline: Lions -196, Total: 50.5

Lions vs 49ers Best Bet: Lions -3.5

The Lions enter this game with a chance to clinch a first-round bye regardless of whether they win or lose this battle with the Niners. However, there’s no doubt that Dan Campbell and his squad don’t remember the heartache they felt less than a year ago watching San Francisco celebrate after advancing to the Super Bowl. With Detroit looking to win every game and make a statement, they’ll likely have more motivation this week to win than they would against any other non-divisional opponent. 

Lions vs 49ers Best Total Bet: Over 50.5

The Lions’ offense has been unreal this season, averaging 32.9 points per game. On the flip side, the Niners have arguably struggled offensively more so than they ever have under Kyle Shanahan, averaging 22.1 points per contest. Nonetheless, with a 50.5-point set total, it wouldn’t be a surprise to see both teams put up enough points to get over the mark. A final score of 34-23 seems like a realistic outcome.

Lions Best Player Bet: Jahmyr Gibbs 2+ Touchdowns +220

Jahmyr Gibbs made the second-year leap this season that nearly everyone expected him to after a dominant rookie year. Gibbs has 1,156 rushing yards, 440 receiving yards, and 15 total touchdowns on the season. With David Montgomery still recovering from injury, Gibbs’s volume has increased, which has improved his odds of finding the endzone. Considering how involved he is in both the passing game and rushing attack, mixed with his ability to break any play for a touchdown, the Alabama product could find his way into the endzone more than once on Monday Night Football.

49ers Best Player Bet: Isaac Guerendo 70+ Rushing Yards +138

Isaac Guerendo stepped up to the challenge in the 49ers injury-riddled backfield after Christian McCaffrey and Jordan Mason went down. The running back impressed in his two starts behind the dominant offensive line of the Niners, and while he’s dealing with nagging injuries himself, the fourth-round pick will be playing with a chip on his shoulder to prove he belongs. The 24-year-old could be in for a big night if Shanahan looks to get the ground game going early.

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