NFL Week 4 Betting: Can the Patriots Upset the 49ers?

As the New England Patriots prepare to face the banged-up San Francisco 49ers, this matchup has plenty of intrigue for bettors. The 49ers are dealing with several key injuries, which makes this a much closer game than the spread suggests. With the Patriots coming off extra rest and the 49ers missing key players like Trent Williams, there’s reason to believe New England can keep this game close and potentially pull off the upset.

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The 49ers’ Injury Woes: Will It Impact the Game?

The San Francisco 49ers have been one of the most dominant teams in the NFL, but injuries are starting to pile up. Trent Williams, their All-Pro left tackle, is questionable, and without him, the 49ers’ offense could struggle to protect Brock Purdy. Additionally, while Deebo Samuel is expected to return, his health may limit his effectiveness. These injuries create uncertainty for a team that has relied heavily on its physical style of play.

With the 49ers’ injury situation, betting on New England +10.5 feels like a smart play. The Patriots, with extra rest after a Thursday night game, are in a good spot to keep this game competitive, especially if San Francisco’s offensive line is compromised.

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Patriots’ Rest Advantage: The Mini Bye Week

The Patriots come into this game with extra rest, having played on Thursday night in the previous week. This “mini-bye" can give teams a significant advantage, especially when preparing for tough opponents. New England will likely lean heavily on Rhamondre Stevenson, who has been a consistent red-zone threat and could take advantage of a weakened 49ers defense.

Consider Rhamondre Stevenson anytime touchdown scorer as a prop bet this week. With the Patriots focusing on the run game to control the clock and keep the 49ers’ offense off the field, Stevenson is likely to be a key part of their game plan.

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Jauan Jennings: The X-Factor for the 49ers

While the 49ers may be missing some of their stars, Jauan Jennings has emerged as a solid contributor to the offense. Jennings has proven to be a reliable target, particularly in red-zone situations, and could see increased involvement if the Patriots focus on shutting down Brandon Aiyuk and Deebo Samuel.

Look for Jauan Jennings anytime touchdown scorer as a sneaky prop bet this week. With defenses focusing on the 49ers’ primary weapons, Jennings could see more opportunities in the passing game, especially near the goal line.

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Patriots’ Betting Outlook: A Strong Case for the Upset

The Patriots come into this game as significant underdogs (+10.5), but given the 49ers’ injury issues and New England’s extra rest, this spread feels too wide. If the 49ers are without Trent Williams, their ability to control the line of scrimmage could be compromised, giving the Patriots a real chance to make this a competitive game.

Betting on New England to cover the spread (+10.5) is an appealing option. Additionally, if you believe in the Patriots’ ability to pull off the upset, consider sprinkling some money on Patriots moneyline at +350. It’s a high-risk, high-reward bet, but the circumstances surrounding this game make it a possibility.

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The Total Points: Should You Bet the Over or Under?

With the 49ers dealing with injuries and the Patriots likely leaning on the run game, this could be a lower-scoring affair. The current total sits around 43.5 points, and both teams could struggle to generate enough offense to hit the over.

Consider betting the under 43.5 total points. If the Patriots are able to slow the game down with their run-heavy attack, and the 49ers are limited by injuries, this could turn into a defensive battle.

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Conclusion: Patriots vs. 49ers Betting Breakdown

This matchup between the Patriots and 49ers offers plenty of betting opportunities. With the 49ers dealing with injuries and the Patriots coming off extra rest, betting on New England to cover the +10.5 spread feels like a strong play. Rhamondre Stevenson and Jauan Jennings offer intriguing prop bet options, while the total points line suggests this could be a lower-scoring game than expected.

Top Betting Picks:

• New England +10.5
• Rhamondre Stevenson anytime touchdown scorer
• Jauan Jennings anytime touchdown scorer
• Total points under 43.5
• Patriots moneyline +350 (upset potential)

The Patriots could surprise many this week with their ability to keep the game close, making this a must-watch game for bettors.

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