Rams vs 49ers TNF Week 15 Predictions | NFL Picks Today, Best Bets

The Los Angeles Rams are set for an in-state showdown against the San Francisco 49ers on Thursday Night Football. As each team hopes to stay alive in the NFC Conference playoff race, this matchup will be a must-win for both squads. The Niners enter this matchup shorthanded with the recent loss of Christian McCaffrey and Jordan Mason, who landed on IR with injuries over the past couple of weeks. Nonetheless, with Kyle Shanahan leading the way, San Francisco always has a chance. Meanwhile, the Rams and Sean McVay seem to be finding their groove, as they have won three of their last four games.

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Rams vs 49ers

• Location: Levi’s Stadium (Santa Clara, California) | Time: 8:15 PM ET
• Where to Watch: Amazon Prime Video
• Spread: 49ers -3, Moneyline: 49ers -142, Total: 49.5

Rams vs 49ers Best Bet: Rams ML +120

The Rams enter this battle as the underdogs despite entering fresh off a thrilling win over the Buffalo Bills on Sunday Night Football. Los Angeles’ offense has continued to impress all season long, and they’ve shown they can put up points in a hurry, whether at home or on the road. This matchup could come down to who wins the chess match between Shanahan and McVay, but based on the way the Rams have been playing recently, it won’t be a surprise to see them steal a win on the road.

Rams vs 49ers Best Total Bet: Over 49.5

The Rams enter this matchup averaging 22.9 points per game, trailing just behind the 49ers, who average 23.7. On the flip side, Los Angeles’ defense allows opposing teams to score 25.5 points per game, while San Francisco allows 23.7 points per game to opponents. In what could be a fun back-and-forth shootout, this game could be an outlier game for both sides as they trade shots in the second half. A final score of 31-27 seems realistic.

Rams Best Player Bet: Cooper Kupp 70+ Receiving Yards +124

Cooper Kupp has quietly returned to his former self as one of Matthew Stafford’s top targets in the Rams high-powered offense. The wideout is up to 657 receiving yards and six touchdowns this season despite missing over a month of play due to an early injury. Since returning, Kupp has surpassed the 70+ receiving yard mark four times, two of which have come in the last four weeks. Against a stout defensive line, the Rams could rely on Stafford and his receiving group to get the job done on Thursday.

49ers Best Player Bet: Jauan Jennings Any Time Touchdown +135

Jauan Jennings has emerged as one of the most reliable pass catchers for the 49ers this season, especially after Brandon Aiyuk was ruled out for the season with a torn ACL. The Tennessee product is in the midst of a career year where he’s racked up 57 receptions for 774 receiving yards and six touchdowns up to this point. Coming off a two-touchdown performance last weekend, it wouldn’t be a shock to see Jennings end up in the endzone again, especially with how underwhelming the Rams’ secondary has been this season.

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