Week 6 NFL Betting Guide: Best Bet, Prop, Predictions for Sunday & Monday Games

We set you up for Week 6 with our NFL Betting Guide.

Thursday Night 49ers-Seahawks Recap

Check out SportsGrid’s NFL game picks and NFL Props Picks all Season Long.

Bye Week: Kansas City Chiefs, Los Angeles Rams, Miami Dolphins, Minnesota Vikings

9:30 a.m ET: Jacksonville Jaguars (1-4) vs. Chicago Bears (3-2): Preview

• Spread: Bears -1.5 | Moneyline: Bears -116 | Total: 44.5
• Where to Watch: NFL Network | Location: Tottenham Hotspur Stadium (London, UK)

SportsGrid’s Best Bets: Jaguars +1.5 (5-Stars) | UNDER 44.5 (5-Stars)

SportsGrid’s Predicted Game Outcome: Jaguars by 3 Points

SportsGrid’s Top Props: Brian Thomas Jr. Anytime TD (5-Stars, +180) | Cole Kmet OVER 15.5 Longest Reception (5-Stars)

1:00 p.m ET: Cleveland Browns (1-4) @ Philadelphia Eagles (2-2): Preview

• Spread: Eagles -9.5 | Moneyline: Eagles -480 | Total: 42.5
• Where to Watch: FOX | Location: Lincoln Financial Field (Philadelphia, PA)

SportsGrid’s Best Bets: Browns +9.5 (4-Stars) | OVER 42.5 (5-Stars) 

SportsGrid’s Predicted Game Outcome: Eagles by 8 Points

SportsGrid’s Top Props: Amari Cooper Anytime TD (5-Stars, +310) | AJ Brown Longest Reception OVER 25.5 (5-Stars)

1:00 p.m ET: Tampa Bay Buccaneers (3-2) @ New Orleans Saints (2-3): Preview

• Spread: Buccaneers -3.5 | Moneyline: Buccaneers -180 | Total: 41.5
• Where to Watch: FOX | Location: Caesars Superdome (New Orleans, LA)

SportsGrid’s Best Bets: Buccaneers -3.5 (5-Stars) | UNDER 41.5 (5-Stars)

SportsGrid’s Predicted Game Outcome: Buccaners by 6 Points

SportsGrid’s Top Props: Awating Props

1:00 p.m ET: Arizona Cardinals (2-3) @ Green Bay Packers (3-2): Preview

• Spread: Packers -5.5 | Moneyline: Packers -255 | Total: 47.5
• Where to Watch: FOX | Location: Lambeau Field (Green Bay, WI)

SportsGrid’s Best Bets: Cardinals +5.5 (5-Stars) | Cardinals ML (+205) | OVER 47.5 (2-Stars)

SportsGrid’s Predicted Game Outcome: Packers by 2 Points

SportsGrid’s Top Props: Marvin Harrison Jr. First Touchdown (5-Stars, +1200) | Tucker Kraft Anytime TD (5-Stars, +200)

1:00 p.m ET: Indianapolis Colts (2-3) @ Tennessee Titans (1-3): Preview

• Spread: Titans -2.5 | Moneyline: Titans -158 | Total: 42.5
• Where to Watch: CBS | Location: Nissan Stadium (Nashville, TN)

SportsGrid’s Best Bets: Titans -2.5 (1-Star) | UNDER 42.5 (3-Stars)

SportsGrid’s Predicted Game Outcome: Titans by 3 Points

SportsGrid’s Top Props: Will Levis UNDER 1.5 Passing Touchdowns (4.5-Stars) | Tyjae Spears Anytime TD (5-Stars, +200)

1:00 p.m ET: Houston Texans (4-1) @ New England Patriots (1-4) 

• Spread: Texans -6.5 | Moneyline: Texans -300 | Total: 37.5
• Where to Watch: CBS | Location: Gillette Stadium (Foxborough, MA)

SportsGrid’s Best Bets: Texans -6.5 (1-Star) | UNDER 37.5 (5-Stars)

SportsGrid’s Predicted Game Outcome: Texans by 7 Points

SportsGrid’s Top Props: Tank Dell UNDER 56.5 Receiving Yards (5-Stars) | Drake Maye UNDER 28.5 Passing Attempts (5-Stars)

1:00 p.m ET: Washington Commanders (4-1) @ Baltimore Ravens (3-2): Preview

• Spread: Ravens -6.5 | Moneyline: Ravens -320 | Total: 51.5
• Where to Watch: CBS | Location: M&T Bank Stadium (Baltimore, MD)

SportsGrid’s Best Bets: Commanders +6.5 (5-Stars) | Commanders ML (4-Stars, +260) | OVER 51.5 (5-Stars)

SportsGrid’s Predicted Game Outcome: Ravens by 4 Points

SportsGrid’s Top Props: Jayden Daniels Anytime TD (5-Stars, +150) | Isaiah Likely Anytime TD (5-Stars, +290)

4:05 p.m ET: Los Angeles Chargers (2-2) @ Denver Broncos (3-2)

• Spread: Chargers -3 | Moneyline: Chargers -162 | Total: 35.5
• Where to Watch: CBS | Location: Empower Field at Mile High (Denver, CO)

SportsGrid’s Best Bets: Chargers -3 (5-Stars) | UNDER 35.5 (2-Stars)

SportsGrid’s Predicted Game Outcome: Chargers by 4 Points

SportsGrid’s Top Props: Quentin Johnston Anytime TD (5-Stars, +320) | Josh Reynolds Anytime TD (5-Stars, +600)

4:05 p.m ET: Pittsburgh Steelers (3-2) @ Las Vegas Raiders (2-3)

• Spread: Steelers -3 | Moneyline: Steelers -162 | Total: 36.5
• Where to Watch: CBS | Location: Allegiant Stadium (Las Vegas, NV)

SportsGrid’s Best Bets: Steelers -3 (5-Stars) | UNDER 36.5 (5-Stars)

SportsGrid’s Predicted Game Outcome: Steelers by 5 Points

SportsGrid’s Top Props: Awaiting Props

4:25 p.m ET: Atlanta Falcons (3-2) @ Carolina Panthers (1-4) 

• Spread: Falcons -6.5 | Moneyline: Falcons -260 | Total: 46.5
• Where to Watch: FOX | Location: Bank of America Stadium (Charlotte, NC)

SportsGrid’s Best Bets: Falcons -6.5 (4-Stars) | UNDER 46.5 (5-Stars)

SportsGrid’s Predicted Game Outcome: Falcons by 8 Points

SportsGrid’s Top Props: Kyle Pitts OVER 16.5 Longest Reception (5-Stars) | Diontae Johnson OVER 21.5 Longest Reception (5-Stars)

4:25 p.m ET: Detroit Lions (3-1) @ Dallas Cowboys (3-2): Preview

• Spread: Lions -3 | Moneyline: Lions -172 | Total: 52.5
• Where to Watch: FOX | Location: AT&T Stadium (Arlington, TX)

SportsGrid’s Best Bet: UNDER 52.5 (5-Stars) 

SportsGrid’s Predicted Game Outcome: Lions by 3 Points

SportsGrid’s Top Props: Dak Prescott OVER 37.5 Passing Attempts (5-Stars) | Jameson Williams Anytime TD (5-Stars, +185)

8:20 p.m ET: Cincinnati Bengals (1-4) @ New York Giants (2-3)

• Spread: Bengals -3.5 | Moneyline: Bengals -180 | Total: 47.5
• Where to Watch: NBC | Location: Metlife Stadium (East Rutherford, NJ)

SportsGrid’s Best Bets: Bengals -3.5 (1-Star) | UNDER 47.5 (5-Stars)

SportsGrid’s Predicted Game Outcome: Bengals by 4 Points

SportsGrid’s Top Props: Tee Higgins OVER 54.5 Receiving Yards (5-Stars)

Monday, 8:15 p.m ET: Buffalo Bills (3-2) @ New York Jets (2-3): Preview

• Spread: Bills -2.5 | Moneyline: Bills -142 | Total: 40.5
• Where to Watch: ESPN | Location: Metlife Stadium (East Rutherford, NJ)

SportsGrid’s Best Bets: Bills -2.5 (5-Stars) | UNDER 40.5 (4-Stars)

SportsGrid’s Predicted Game Outcome: Bills by 5 Points

SportsGrid’s Top Props: Khalil Shakir Anytime TD (5-Stars, +270) | Allen Lazard Anytime TD (5-Stars, +310)

All Odds Courtesy of FanDuel Sportsbook