College Football Odds Week 2: Biggest NCAAF Spreads This Week

A terrific slate of games is on the schedule for Week 2 of the 2023 college football season. That being said, some teams are heavily favored to roll right over overmatched opponents.

According to BetMGM Sportsbook’s college football odds, here are the biggest spreads this week.

College Football Odds Week 2: Biggest NCAAF Spreads This Week

Rank	Matchup	Spread
1	Ball State at Georgia	Georgia -42.5
2	Kent State at Arkansas	Arkansas -38.5
3	UNLV at Michigan	Michigan -35.5
4	Tulsa at Washington	Washington -34.5
5	Southern Miss at Florida State	Florida State -30.5
6	Stanford at USC	USC -29.5
7	Charlotte at Maryland	Maryland -24.5
8	Western Michigan at Syracuse	Syracuse -23.5
9	Memphis at Arkansas State	Memphis -21.5
10	Middle Tennessee at Missouri	Missouri -21

1. Ball State at Georgia (-42.5)

The defending national champs won 48-7 in Week 1 and will look for a second lopsided victory. This will be the second straight game against an SEC team for the Ball State Cardinals, who fell 44-14 to the Kentucky Wildcats a week ago. 

2. Kent State at Arkansas (-38.5)

Sam Pittman and the Hogs rolled to an easy 56-13 game against the Western Carolina Catamounts in Week 1 and will look for a second victory by a significant margin in Fayetteville. KJ Jefferson and Raheim Sanders lead the offense while the defense looks for improved play in the secondary, which likely won’t be tested with regularity in this matchup.  

3. UNLV at Michigan (-35.5)

This will be the second game of Jim Harbaugh’s three-game suspension, but the oddsmakers don’t think that will matter much in this contest. His team coasted to a 30-3 victory over the East Carolina Pirates in Week 1 and faces a new-look UNLV Rebels team in Year 1 of the Barry Odom era. Early returns on the Rebels were mixed as they were outgained 409 to 394 total yards by an FCS team despite winning by a margin. 

4. Tulsa at Washington (-34.5)

Michael Penix Jr. started his Heisman campaign strong, completing 29 of 40 attempts for 450 passing yards and five touchdowns against the Boise State Broncos in Week 1. He’ll look for another strong showing as the Huskies are favored by nearly five touchdowns against the Tulsa Golden Hurricane. Tulsa is in Year 1 under Kevin Wilson and may be without their starting quarterback after Braylon Braxton departed early a week ago. 

5. Southern Miss at Florida State (-30.5)

Arguably the biggest winner of Week 1, the Florida State Seminoles return home after a dominant 45-24 victory over the LSU Tigers. Jordan Travis will look to pad his stats to strengthen his Heisman resume, although the Southern Miss Golden Eagles are no pushover under Will Hall. 

6. Stanford at USC (-29.5) 

Troy Taylor had his team looking pretty good in a 37-24 road victory over the Hawaii Rainbow Warriors in Week 1. The second game of his Stanford Cardinal tenure is expected to be much more difficult as his squad is tasked with stopping the reigning Heisman trophy winner, Caleb Williams. Lincoln Riley and the USC Trojans have had a manageable schedule early on, and that does not change as they look to move to 3-0 on the young season.

7. Charlotte at Maryland (-24.5)

Biff Poggi and the Charlotte 49ers had about as much roster turnover as any team in the country. They travel to face a Maryland Terrapins team led by four-year starter Taulia Tagovailoa at quarterback. An interesting note for this game is that Charlotte offensive coordinator Mike Miller spent the last four years with the Terps. 

8. Western Michigan at Syracuse (-23.5)

Dino Babers and the Syracuse Orange rolled to a 65-0 victory over the Colgate Raiders in Week 1. They’ll look for continued success against the Western Michigan Broncos, who look to be a decent offensive group with a new system in town but are liable on the defensive side. 

9. Memphis (-21.5) at Arkansas State

It’s safe to say things did not go well for Butch Jones and the Arkansas State Red Wolves in Week 1. They were housed 73-0 by the Oklahoma Sooners and now must pick themselves off the mat as three-score underdogs at home against the Memphis Tigers, led by three-year starter Seth Henigan at quarterback. 

10. Middle Tennessee at Missouri (-21)

Pour one out for the Middle Tennessee State Blue Raiders, who faced the Alabama Crimson Tide in Week 1 and now must bounce back against the Missouri Tigers in Week 2. Talk about a demanding schedule to get things rolling! Rick Stockstill’s bunch is good defensively for a CUSA school but faces a tough test against star receiver Luther Burden.