NFL Week 2 Betting Lines: Biggest NFL Underdogs This Week

With so much parity in the NFL, the phrase “Any Given Sunday” applies on the gridiron with upsets every week. When betting on the NFL, this is always something to consider.

Below are the biggest underdogs of the week.

Rank	Matchup	Favorite	Underdog
1	Las Vegas Raiders vs. Buffalo Bills	Bills -10	Raiders +10
2	San Francisco 49ers vs. Los Angeles Rams	49ers -8.5	Rams +8.5
3	Minnesota Vikings vs. Philadelphia Eagles	Eagles -7.5	Vikings +7.5
4	Seattle Seahawks vs. Detroit Lions	Lions -6	Seahawks +6
5	New York Giants vs. Arizona Cardinals	Giants -4.5	Cardinals +4.5
6. (Tie)	Los Angeles Chargers vs. Tennessee Titans	Chargers -3.5	Titans +3.5
6. (Tie)	Baltimore Ravens vs. Cincinnati Bengals	Bengals -3.5	Ravens +3.5
6. (Tie)	Washington Commanders vs. Denver Broncos	Broncos -3.5	Commanders +3.5
6. (Tie)	New Orleans Saints vs. Carolina Panthers	Saints -3.5	Panthers +3.5

1. Las Vegas Raiders (+10) vs. Buffalo Bills (-10)

The biggest underdog title of Week 2 belongs to the Las Vegas Raiders, who’re ten-point underdogs on the road against the Buffalo Bills. The Raiders snuck by the Denver Broncos in Week 1 and will look to cover for the second straight week. 

2. San Francisco 49ers (-8.5) vs. Los Angeles Rams (+8.5) 

Despite going into their Week 1 game against the Seattle Seahawks as underdogs, the Los Angeles Rams covered the number and won. They’ll have their work cut out for them in Week 2 as they host the San Francisco 49ers as 8.5-point underdogs. 

3. Minnesota Vikings (+7.5) vs. Philadelphia Eagles (-7.5)

Not only did the Minnesota Vikings not cover the spread in Week 1 against the Tampa Bay Buccaneers, but they also lost outright. The Vikings are 7.5-point underdogs in their Week 2 matchup against the Philadelphia Eagles. 

4. Seattle Seahawks (+6) vs. Detroit Lions (-6)

There wasn’t much to write home about for the Seattle Seahawks in Week 1 against the Los Angeles Rams. The Seahawks will look to bounce back on the road in Week 2 as six-point underdogs against the Detroit Lions. 

5. New York Giants (-4.5) vs. Arizona Cardinals (+4.5)

The Arizona Cardinals were one of the largest underdogs in Week 1 action and covered the number against the Washington Commanders. The Cardinals are again 4.5-point underdogs when they host the New York Giants in Week 2. 

6. (Tie) Los Angeles Chargers (-3.5) vs. Tennessee Titans (+3.5)

In one of the more defensive-heavy battles of Week 1, the Tennessee Titans fell short to the New Orleans Saints. Still, the Titans covered the number and are 3.5-point underdogs at home against the Los Angeles Chargers in Week 2. 

6. (Tie) Baltimore Ravens (+3.5) vs. Cincinnati Bengals (-3.5)

The Baltimore Ravens knocked off the Houston Texans by double-digits in Week 1. They’ll be traveling to Cincinnati for a Week 2 AFC North showdown against the defending division champs as 3.5-point underdogs. 

6. (Tie) Washington Commanders (+3.5)  vs. Denver Broncos (-3.5)

Upset watch followed the Washington Commanders in Week 1, and although they came out on top against the Arizona Cardinals, they could not cover the number. The Commanders are 3.5-point underdogs on the road against the Denver Broncos in Week 2. 

6. (Tie) New Orleans Saints (-3.5) vs. Carolina Panthers (+3.5) 

The Carolina Panthers were within striking distance for most of their Week 1 game against the Atlanta Falcons but still lost by two scores. They’re set to enter Week 2 as 3.5-point underdogs at home against the New Orleans Saints. 

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