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The <a href="https://www.sportsgrid.com/nba/depth-chart/la-clippers-depth-chart">LA Clippers</a> are set for a Wednesday night showdown against the <a href="https://www.sportsgrid.com/nba/depth-chart/new-york-knicks-depth-chart">New York Knicks</a>. Tyronn Lue&#8217;s squad enters this matchup having won four of their last five games and looking to carry the momentum on the road as the postseason looms. Meanwhile, the Knicks hope to build on their two-game winning streak as they continue to weather the storm without <a href="https://www.sportsgrid.com/nba/players/jalen-brunson/2809">Jalen Brunson</a>, who is recovering from an ankle injury. With both teams fighting for seeding in their respective conferences, expect this matchup to be a dogfight.
<oc-offers-widget slot-id="8BWVycnZ9RVnrscXWaJZb" placeholders="TEAM_1=LA Clippers|TEAM_2=New York Knicks" override-url="https://sportsgrid.com/"></oc-offers-widget>
<h2><a href="https://www.sportsgrid.com/nba/game/la-clippers-new-york-knicks-scores-odds-picks-props-march-26-2025/637ecfa1-8b50-4056-ab48-df7492b4bba5">Clippers vs Knicks</a></h2>
<ul>
<li>Location: Madison Square Garden &#8211; New York, NY</li>
<li>Where to Watch: ClipperVision/NBA League Pass</li>
<li>Time: 7:30 p.m. ET</li>
<li>Spread: Clippers -3.5 | Total: 218.5</li>
<li>Moneyline: Clippers -164 | Knicks +138</li>
</ul>
Please be aware that betting odds may change after the publication of this article.
<h2>Clippers vs Knicks Best Bet: Clippers -3.5</h2>
The Clippers entered this season with seemingly more pessimism around their roster than optimism after losing <a href="https://www.sportsgrid.com/nba/players/paul-george/3131">Paul George</a> in free agency. Despite that, LA has quietly done a solid job making moves to make the team one of the deepest rosters in the league. Regardless of injuries, it seems like Tyronn Lue always has a viable option to fill in, irrespective of the position. Between the talent on the Clippers and the fact that they have more depth while dealing with injuries, I like the odds that LA steals a win on the road by more than four points.
<h2>Clippers vs Knicks Best Total Bet: Over 218.5</h2>
These two squads have matched up once this season, and it was in early March. The Clippers came out on top by double digits, but they also had the home court advantage in the win. This game could be close, but I still like the chances that the Clippers come out on top. Regardless, a final score of 114-108 seems like a realistic outcome in this showdown.
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<h2>Clippers Best Player Bet: Norman Powell 20+ Points Scored +144</h2>
<a href="https://www.sportsgrid.com/nba/players/norman-powell/3133">Norman Powell</a> was considered one of the biggest snubs after not being named to an All-Star team despite leading the Clippers in points per game with 22.7. The UCLA product has struggled lately since returning from injury, but he has the talent to explode for 20+ points on any given night, and he&#8217;s proven that not only this season, but throughout his career. Eventually, the guard will find his way out of the shooting slump, and in a marquee matchup in Madison Square Garden, there&#8217;s no better time than now.
<h2>Knicks Best Player Bet: Karl-Anthony Towns 3+ Made Threes +136</h2>
<a href="https://www.sportsgrid.com/nba/players/karl-anthony-towns/2969">Karl-Anthony Towns</a> has picked up the slack on offense since Brunson went down with an injury showing exactly why the Knicks were so comfortable to make the blockbuster trade to acquire him in the offseason. The Kentucky product is a three-level scorer who can use his size in the paint, knock down mid-range shots, and make opposing defenses pay from beyond the arc. In his last matchup against the Clippers, Towns finished with three makes from downtown in seven attempts. Assuming he&#8217;s just as aggressive tonight, I like the chance that the 42.5% three-point shooter can make 3+ threes.
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The LA Clippers are set for Wednesday's conference clash against the New York Knicks. Here's what you need to know before tip-off in this marquee matchup.

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