Week 10 NFL Betting Guide: Best Bet, Prop, Predictions for Sunday & Monday Games

We set you up for Week 10 with our NFL Betting Guide.

Thursday Night Football Recap: Ravens Edge Bengals in AFC North Battle | Ja’Marr Chase’s Stellar Showing

Week 10 Top Insights: Ranking Most Likely Super Bowl Matchups | Christian McCaffrey Set for Return 

Bye Week: Cleveland Browns, Green Bay Packers, Las Vegas Raiders, Seattle Seahawks

Check out SportsGrid’s NFL game picks and NFL Props Picks all Season Long.

9:30 p.m. ET: New York Giants (2-7) vs. Carolina Panthers (2-7)

• Spread: Giants -6.5 | Moneyline: Giants -270 | Total: 40.5
• Where to Watch: NFL Network | Location: Allianz Arena (Munich, Germany)

SportsGrid’s Best Bets: Giants -6.5 (5-Stars)

SportsGrid’s Predicted Game Outcome: Giants by 10 points

SportsGrid’s Top Props: Daniel Jones UNDER 31.5 Passing Attempts (5-Stars) | Bryce Young UNDER 28.5 Passing Attempts (5-Stars)

1:00 p.m. ET: San Francisco 49ers (4-4) @ Tampa Bay Buccaneers (4-5)

• Spread: 49ers -6.5 | Moneyline: 49ers -270 | Total: 50.5
• Where to Watch: FOX | Location: Raymond James Stadium (Tampa, FL)

SportsGrid’s Best Bets: 49ers -6.5 (5-Stars) | UNDER 50.5 (4-Stars)

SportsGrid’s Predicted Game Outcome: 49ers by 9 points

SportsGrid’s Top Props: George Kittle First Touchdown (5-Stars, +1000) | Baker Mayfield OVER 1.5 Passing Touchdowns (5-Stars, +100)

1:00 p.m. ET: Atlanta Falcons (6-3) @ New Orleans Saints (2-7)

• Spread: Falcons -3.5 | Moneyline: Falcons -196 | Total: 46.5
• Where to Watch: FOX | Location: Caesars Superdome (New Orleans, LA)

SportsGrid’s Best Bets: Falcons -3.5 (4-Stars) | UNDER 46.5 (5-Stars)

SportsGrid’s Predicted Game Outcome: Falcons by 5 points

SportsGrid’s Top Props: Drake London First Touchdown (5-Stars, +750) 

1:00 p.m. ET: Buffalo Bills (7-2) @ Indianapolis Colts (4-5)

• Spread: Bills -3.5 | Moneyline: Bills -205 | Total: 47.5
• Where to Watch: CBS | Location: Lucas Oil Stadium (Indianapolis, IN)

SportsGrid’s Best Bets: Bills -3.5 (5-Stars) | UNDER 47.5 (5-Stars)

SportsGrid’s Predicted Game Outcome: Bills by 6 points

SportsGrid’s Top Props: Josh Allen OVER 32.5 Passing Attempts (5-Stars) | Joe Flacco UNDER 34.5 Passing Attempts (5-Stars)

1:00 p.m. ET: Pittsburgh Steelers (6-2) @ Washington Commanders (7-2): Preview

• Spread: Commanders -2.5 | Moneyline: Commanders -146 | Total: 44.5
• Where to Watch: CBS | Location: Northwest Stadium (Landover, MD)

SportsGrid’s Best Bets: Commanders -2.5 (1-Star) | OVER 44.5 (2-Stars)

SportsGrid’s Predicted Game Outcome: Commanders by 3 points

SportsGrid’s Top Props: Russell Wilson Anytime TD (5-Stars, +550) | Brian Robinson Jr. (5-Stars, +600)

1:00 p.m. ET: Minnesota Vikings (6-2) @ Jacksonville Jaguars (2-7)

• Spread: Vikings -7 | Moneyline: Vikings -330 | Total: 44.5
• Where to Watch: FOX | Location: EverBank Stadium (Jacksonville, FL)

SportsGrid’s Best Bets: Vikings -7 (3-Stars) | UNDER 44.5 (5-Stars)

SportsGrid’s Predicted Game Outcome: Vikings by 8 points

SportsGrid’s Top Props: Aaron Jones UNDER 17.5 Rushing Attempts (5-Stars) | Brian Thomas Jr. Anytime TD (5-Stars, +210)

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1:00 p.m. ET: New England Patriots (2-7) @ Chicago Bears (4-4)

• Spread: Bears -6.5 | Moneyline: Bears -275 | Total: 38.5
• Where to Watch: FOX | Location: Soldier Field (Chicago, IL)

SportsGrid’s Best Bets: Patriots +6.5 (1-Star) | OVER 38.5 (2-Stars)

SportsGrid’s Predicted Game Outcome: Bears by 6 points

SportsGrid’s Top Props: Hunter Henry Longest Reception OVER 17.5 Yards (5-Stars) | DJ Moore Anytime TD (5-Stars, +200)

1:00 p.m. ET: Denver Broncos (5-4) @ Kansas City Chiefs (8-0)

• Spread: Chiefs -7.5 | Moneyline: Chiefs -370 | Total: 41.5
• Where to Watch: CBS | Location: GEHA Field at Arrowhead (Kansas City, MO)

SportsGrid’s Best Bets: Broncos +7.5 (4-Stars) | Broncos ML (2-Stars) | OVER 41.5 (4-Stars)

SportsGrid’s Predicted Game Outcome: Chiefs by 6 points

SportsGrid’s Top Props: Bo Nix Anytime TD (5-Stars, +350) | Kareem Hunt First TD (5-Stars, +410)

4:05 p.m. ET: Tennessee Titans (2-6) @ Los Angeles Chargers (5-3)

• Spread: Chargers -7.5 | Moneyline: Chargers -340 | Total: 38.5
• Where to Watch: FOX | Location: Sofi Stadium (Inglewood, CA)

SportsGrid’s Best Bets: Titans +7.5 (5-Stars) | Titans ML (4-Stars, +275) | OVER 38.5 (5-Stars)

SportsGrid’s Predicted Game Outcome: Chargers by 5 points

SportsGrid’s Top Props: Chig Okonkwo Longest Reception OVER 11.5 Yards (5-Stars) | Ladd McConkey Longest Reception OVER 20.5 Yards (5-Stars)

4:25 p.m. ET: New York Jets (3-6) @ Arizona Cardinals (5-4)

• Spread: Jets -1.5 | Moneyline: Jets -126 | Total: 46.5
• Where to Watch: CBS | Location: State Farm Stadium (Glendale, AZ)

SportsGrid’s Best Bets: Cardinals +1.5 (1-Star) | UNDER 46.5 (3-Stars)

SportsGrid’s Predicted Game Outcome: Jets by 1 point

SportsGrid’s Top Props: Braelon Allen Anytime TD (5-Stars, +400) | Michael Wilson Anytime TD (5-Stars)

4:25 p.m. ET: Philadelphia Eagles (6-2) @ Dallas Cowboys (3-5): Preview

• Spread: Eagles -7 | Moneyline: Eagles -370 | Total: 43.5
• Where to Watch: CBS | Location: AT&T Stadium (Arlington, TX)

SportsGrid’s Best Bets: Eagles -7 (3-Stars) | UNDER 43.5 (5-Stars)

SportsGrid’s Predicted Game Outcome: Eagles by 8 points

SportsGrid’s Top Props: Jalen Hurts UNDER 27.5 Passing Attempts (5-Stars) | Cooper Rush UNDER 33.5 Passing Attempts (5-Stars)

8:20 p.m. ET: Detroit Lions (7-1) @ Houston Texans (6-3): Preview

• Spread: Lions -3.5 | Moneyline: Lions -178 | Total: 48.5
• Where to Watch: NBC | Location: NRG Stadium (Houston, TX)

SportsGrid’s Best Bets: Lions -3.5 (5-Stars) | UNDER 48.5 (5-Stars)

SportsGrid’s Predicted Game Outcome: Lions by 6 points

SportsGrid’s Top Props: Jared Goff OVER 1.5 Passing Touchdowns (5-Stars, +108) | Joe Mixon OVER 18.5 Rushing Attempts (5-Stars)

Monday, 8:15 p.m. ET: Miami Dolphins (2-6) @ Los Angeles Rams (4-4)

• Spread: Rams -1.5 | Moneyline: Rams -116 | Total: 50.5
• Where to Watch: ESPN | Location: Sofi Stadium (Los Angeles, CA)

SportsGrid’s Best Bets: Dolphins +1.5 (5-Stars) | Dolphins ML (2.5-Stars) | UNDER 50.5

SportsGrid’s Predicted Game Outcome: Dolphins by 2 points

SportsGrid’s Top Props: Tyreek Hill UNDER 73.5 Receiving Yards (5-Stars) | Cooper Kupp Longest Reception OVER 20.5 Reception (5-Stars)

All Odds Courtesy of FanDuel Sportsbook