Friday’s NCAA Women’s Sweet 16 ATS Picks: Lay With South Carolina

No. 4 Gonzaga vs. No. 1 Texas- Regional 4 in Portland | Friday, 10:00 p.m. ET | ESPN

This may be the best chance for an upset as the Bulldogs face the Longhorns. Gonzaga will need Kaylynne Truong to continue her hot shooting from three. She is hitting 43 percent of her three-point shots. Texas allows just 57.4 points per game as a suffocating defense must show up, and Madison Booker must play her best to pull out the win.

The Pick: Gonzaga +6.5

No. 3 Oregon State vs. No. 2 Notre Dame - Regional 1 in Albany | Friday, 2:30 p.m. ET | ESPN

The Irish snuck in under the radar. Hannah Hidalgo averages 22.9 points per game for Notre Dame. Oregon State’s Raegan Beers can shoot well, but Notre Dame’s defense should be the difference in this one.

The Pick: Notre Dame -3.5

No. 4 Indiana vs. No. 1 South Carolina- Regional 1 in Albany | Friday, 5:00 p.m. ET | ESPN

The Gamecocks are the Tournament’s top seed and are undefeated this season. They are heavy favorites, but that’s not a shot at the Hoosiers. IU is coming off a close win over Oklahoma, and after a season where injuries played a significant role, they are finally getting healthy. South Carolina is deeper than IU and is on a mission to win another national championship. This is also a great coaching matchup between Dawn Staley and Teri Moren.

The Pick: South Carolina -16.5

No. 3 NC State vs. No. 2 Stanford- Regional 4 in Portland | Friday, 7:30 p.m. ET | ESPN

NC State and Stanford survived their second-round matchups on their home courts. Kiki Iriafen put up 41 points in the Cardinal win over Iowa State. She will be a handful for the Wolfpack to guard. NC State can outshoot everyone and are 19-0 when they outshoot their opponents this season.

The Pick: Stanford -4.5

No. 4 Gonzaga vs. No. 1 Texas- Regional 4 in Portland | Friday, 10:00 p.m. ET | ESPN

This may be the best chance for an upset as the Bulldogs face the Longhorns. Gonzaga will need Kaylynne Truong to continue her hot shooting from three. She is hitting 43 percent of her three-point shots. Texas allows just 57.4 points per game as a suffocating defense must show up, and Madison Booker must play her best to pull out the win.

The Pick: Gonzaga +6.5