USC vs. Michigan Prediction | College Football Picks Today | Best Bets 

Entering Week 4, the Trojans and Wolverines are set to go head-to-head. USC and Michigan lost vital pieces to their teams in the draft last year and have done their best to replace what they’ve lost. While the Trojans look to be one of the best teams in the nation, Michigan is still searching for a reliable starting quarterback. USC will have the chance to prove they’re a contender as they travel on the road in a hostile environment to take on the Wolverines. 

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USC vs. Michigan

Location: Michigan Stadium (Ann Arbor, Michigan) Time: 3:30 p.m. ET Where to Watch: CBS
Spread: USC -5.5, Moneyline: -220, Total: 44.5

USC vs. Michigan Best Bet: USC -220

The Trojans won their Week 1 matchup against LSU in a close game. However, USC dominated their Week 2 matchup the following week. With a week off, Lincoln Riley’s squad travels to Michigan to play a Wolverine team struggling to find consistency on either side of the ball. USC is in an excellent spot to continue their undefeated season. 

USC vs. Michigan Best Total Bet: Under 44.5

This game could be one of the ugliest of the year. USC could have some lapses on offense in the hostile environment, and Michigan will likely rely on a read-option offense with Alex Orji named the starter. The Trojans could very well win with a final score of 24-17. 

USC Best Player Bet: Woody Marks First Touchdown Scorer +450

Woody Marks has undoubtedly been the best player on the Trojan’s offense up to this point. The running back is up to 171 rushing yards and three touchdowns and could be in line to find the endzone first during Saturday’s matchup. 

Michigan Best Player Bet: Donovan Edwards +120 Any Time Touchdown

Donovan Edwards was hyped up to be the next big thing at Michigan after Blake Corum’s departure in the draft. Edwards has had some moments through the first few weeks, but the offensive struggles have done him no favors. Nonetheless, with the Wolverines likely leaning towards a run-heavy offense, they could look to get Edwards involved more, which could lead to scoring opportunities. A risk worth the reward.

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