Dick Vitale’s 2025 NCAA Tournament Picks, Final Four, and Champion

Dick Vitale Picks: National Championship

(1) Duke over (1) Florida

NCAA Tournament Bracket Busters: Top 10 First-Round Most Likely Upsets

CHAMPIONSHIP ODDS (via Bet365)

Duke +300

Florida +375

Dick Vitale Picks: East Region

Round of 64:

(1) Duke over (16) American/Mt St. Mary’s

(8) Mississippi State over (9) Baylor

(5) Oregon over (12) Liberty

(4) Arizona over (13) Akron

(11) VCU over (6) BYU

(3) Wisconsin over (14) Montana

(7) Saint Mary’s over (10) Vanderbilt

(2) Alabama over (15) Robert Morris

Round of 32: 

(1) Duke over (8) Mississippi State

(4) Arizona over (5) Oregon

(3) Wisconsin over (11) VCU

(2) Alabama over (7) Saint Mary’s

Sweet 16:

(1) Duke over (4) Arizona

(2) Alabama over (3) Wisconsin

Elite 8:

(1) Duke over (2) Alabama

March Madness East Region: Odds, Picks, Cinderella and Winner

EAST REGION ODDS (via bet365) 

Duke: -135 

Alabama: +425 

Arizona: +850 

Wisconsin: +1000 

BYU: +1800 

Saint Mary's: +2200 

Oregon: +3000 

Baylor: +3500 

Mississippi State: +4000 

Vanderbilt: +4000 

VCU: +7500 

Liberty: +20000 

Akron: +25000 

Montana: +25000 

Mt. St. Mary's: +50000 

Robert Morris: +50000

Dick Vitale Picks: Midwest Region

Round of 64:

(1) Houston over (16) SIU Edwardsville

(8) Gonzaga over (9) Georgia

(5) Clemson over (12) McNeese

(4) Purdue over (13) High Point

(6) Illinois over (11) Texas/Xavier

(3) Kentucky over (14) Troy

(7) UCLA over (10) Utah State

(2) Tennessee over (15) Wofford

Round of 32:

(1) Houston over (8) Gonzaga

(4) Purdue over (5) Clemson

(3) Kentucky over (6) Illinois

(2) Tennessee over (7) UCLA

Sweet 16:

(1) Houston over (4) Purdue

(2) Tennessee over (3) Kentucky

Elite 8:

(1) Houston over (2) Tennessee 

March Madness Midwest Region: Odds, Picks, Cinderella, and Winner

MIDWEST REGION ODDS (via bet365) 

Houston: +120 

Tennessee: +350 

Gonzaga: +850 

Kentucky: +1000 

Illinois: +1200 

Clemson: +1400 

Purdue: +1400 

UCLA: +2500 

Georgia: +6000 

McNeese State: +10000 

Utah State: +10000 

Xavier: +10000 

Texas: +12500 

High Point: +20000 

Troy: +30000 

Wofford: +40000 

SIU Edwardsville: +50000

 

Dick Vitale Picks: West Region

Round of 64:

(1) Florida over (16) Norfolk State

(8) UConn over (9) Oklahoma

(12) Colorado State over (5) Memphis

(4) Maryland over (13) Grand Canyon

(11) Drake over (6) Missouri

(3) Texas Tech over (14) UNC-Wilmington

(7) Kansas over (10) Arkansas

(2) St. Johns over (15) Nebraska-Omaha

Round of 32:

(1) Florida over (8) UConn

(12) Colorado State over (4) Maryland

(3) Texas Tech over (11) Drake

(2) St. John’s over (7) Kansas

Sweet 16:

(1) Florida over (12) Colorado State

(2) St. John’s over (3) Texas Tech

Elite 8: 

(1) Florida over (2) St. John’s

West Region Odds (via Bet365) 

Florida: -125 

St. John’s: +550 

Texas Tech: +550 

Maryland: +850 

Kansas: +1600 

Missouri: +1800 

Connecticut: +2200 

Arkansas: +6000 

Colorado State: +6000 

Memphis: +7500 

Oklahoma: +8000 

Drake: +10000 

Grand Canyon: +25000 

UNC Wilmington: +25000 

Omaha: +50000 

Norfolk State: +50000

Dick Vitale Picks: Final Four

(1) Florida over (2) Michigan State

(1) Duke over (1) Houston

March Madness 2025: Top 10 Cinderella Final Four Bracket Busters

FINAL FOUR ODDS (via Bet365)

Florida +200 YES | -250 NO

Auburn +230 YES | -310 NO

Houston +300 YES | -400 NO

Duke +160 YES | -200 NO

Dick Vitale Picks: National Championship

(1) Duke over (1) Florida

NCAA Tournament Bracket Busters: Top 10 First-Round Most Likely Upsets

CHAMPIONSHIP ODDS (via Bet365)

Duke +300

Florida +375