Jay Bilas’s 2025 NCAA Tournament Picks, Final Four, and Champion

Jay Bilas Picks: National Championship

NCAA Tournament Bracket Busters: Top 10 First-Round Most Likely Upsets

(1) Florida over (1) Houston

CHAMPIONSHIP ODDS (via Bet365)

Florida +375

Houston +600

Jay Bilas Picks: East Region

Round of 64:

(1) Duke over (16) American/Mount St. Mary’s
(8) Mississippi State over (9) Baylor
(5) Oregon over (12) Liberty
(4) Arizona over (13) Akron
(6) BYU over (11) VCU
(3) Wisconsin over (14) Montana
(10) Vanderbilt over (7) Saint Mary’s
(2) Alabama over (15) Robert Morris

Round of 32:

(1) Duke over (8) Mississippi State
(2) Alabama over (10) Vanderbilt
(6) BYU over (3) Wisconsin
(4) Arizona over (5) Oregon

Sweet 16:

(1) Duke over (4) Arizona
(2) Alabama over (6) BYU

Elite Eight:

(1) Duke over (2) Alabama

March Madness East Region: Odds, Picks, Cinderella and Winner

EAST REGION ODDS (via bet365)

Duke: -135
Alabama: +425
Arizona: +850
Wisconsin: +1000
BYU: +1800
Saint Mary's: +2200
Oregon: +3000
Baylor: +3500
Mississippi State: +4000
Vanderbilt: +4000
VCU: +7500
Liberty: +20000
Akron: +25000
Montana: +25000
Mt. St. Mary's: +50000
Robert Morris: +50000

Jay Bilas Picks: Midwest Region

Round 64:

(1) Houston over (16) SIU Edwardsville
(8) Gonzaga over (9) Georgia
(5) Clemson over (12) McNeese
(4) Purdue over (13) High Point
(11) Texas over (6) Illinois
(3) Kentucky over (14) Troy
(10) Utah State over (7) UCLA
(2) Tennessee over (15) Wofford

Round of 32:

(1) Houston over (8) Gonzaga
(2) Tennessee over (10) Utah State
(3) Kentucky over (11) Texas
(4) Purdue over (5) Clemson

Sweet 16: 

(1) Houston over (4) Purdue
(2) Tennessee over (3) Kentucky

Elite Eight:

(1) Houston over (2) Tennessee

March Madness Midwest Region: Odds, Picks, Cinderella, and Winner

MIDWEST REGION ODDS (via bet365)

Houston: +120
Tennessee: +350
Gonzaga: +850
Kentucky: +1000
Illinois: +1200
Clemson: +1400
Purdue: +1400
UCLA: +2500
Georgia: +6000
McNeese State: +10000
Utah State: +10000
Xavier: +10000
Texas: +12500
High Point: +20000
Troy: +30000
Wofford: +40000
SIU Edwardsville: +50000

Jay Bilas Picks: West Region

Round of 64:

(1) Florida over (16) Norfolk State
(8) UConn over (9) Oklahoma
(5) Memphis over (12) Colorado State
(4) Maryland over (13) Grand Canyon
(6) Missouri over (11) Drake
(3) Texas Tech over (14) UNC Wilmington
(7) Kansas over (10) Arkansas
(2) St. John’s over (15) Omaha

Round of 32:

(1) Florida over (8) UConn
(2) St. John's over (7) Kansas
(3) Texas Tech over (6) Missouri
(5) Memphis over (4) Maryland

Sweet 16:

(1) Florida over (5) Memphis
(2) St. John's over (3) Texas Tech

Elite Eight:

(1) Florida over (2) St. John's

WEST REGION ODDS (via Bet365)
Florida: -125
St. John’s: +550
Texas Tech: +550
Maryland: +850
Kansas: +1600
Missouri: +1800
Connecticut: +2200
Arkansas: +6000
Colorado State: +6000
Memphis: +7500
Oklahoma: +8000
Drake: +10000
Grand Canyon: +25000
UNC Wilmington: +25000
Omaha: +50000
Norfolk State: +50000

Jay Bilas Picks: Final Four

March Madness 2025: Top 10 Cinderella Final Four Bracket Busters

(1) Florida over (1) Auburn
(1) Houston over (1) Duke

FINAL FOUR ODDS (via Bet365)

Florida +200 YES | -250 NO

Auburn +230 YES | -310 NO

Houston +300 YES | -400 NO

Duke +160 YES | -200 NO

Jay Bilas Picks: National Championship

NCAA Tournament Bracket Busters: Top 10 First-Round Most Likely Upsets

(1) Florida over (1) Houston

CHAMPIONSHIP ODDS (via Bet365)

Florida +375

Houston +600