NFC: San Francisco 49ers (6) at Seattle Seahawks (1)
Prediction: Seahawks win 27-13
The 49ers are limping into this matchup, most notably missing star tight end George Kittle (Achilles). The Seahawks, fresh off a bye and riding a seven-game win streak, are simply the healthier and more complete team right now. Seattle’s defense will feast on a depleted San Francisco unit to secure a comfortable win.