Predicting Every AFC Week 6 Game With Score Projections

Grant White
Host · Writer
The NFL action only intensifies with each passing week, and Week 6 is shaping up to be a doozy. Check out our side, spread, and total predictions for every matchup this week!
Denver Broncos vs. New York Jets
- Stadium: Tottenham Hotspur Stadium
- Location: London, England
- Time: Sunday 9:30 a.m. ET
- Spread: DEN -6.5 | Total: 43.5
- Moneyline: DEN -380 | NYJ +290
Expect a tight defensive battle as the Jets and Broncos get to know each other in London. Jets cover, but Denver wins.
Predicted Outcome: Broncos 16 – Jets 10
Arizona Cardinals vs. Indianapolis Colts
- Stadium: Lucas Oil Stadium
- Location: Indianapolis, IN
- Time: Sunday 1:00 p.m. ET
- Spread: IND -7.5 | Total: 46.5
- Moneyline: IND -360 | ARI +280
The Cardinals’ offense has sputtered this season, and the Colts’ defense will be up to the task.
Predicted Outcome: Colts 28 – Cardinals 18
Los Angeles Rams vs. Baltimore Ravens
- Stadium: M&T Bank Stadium
- Location: Baltimore, MD
- Time: Sunday 1:00 p.m. ET
- Spread: LAR -7.5 | Total: 45.5
- Moneyline: LAR -400 | BAL +300
The Ravens’ offense or defense won’t have an answer for the Rams.
Predicted Outcome: Rams 24 – Ravens 14
Cleveland Browns vs. Pittsburgh Steelers
- Stadium: Acrisure Stadium
- Location: Pittsburgh, PA
- Time: Sunday 1:00 p.m. ET
- Spread: PIT -6.5 | Total: 38.5
- Moneyline: PIT -280 | CLE +230
This will be a classic AFC North battle. Steelers prevail on defense.
Predicted Outcome: Steelers 17 – Browns 14
Seattle Seahawks vs. Jacksonville Jaguars
- Stadium: EverBank Stadium
- Location: Jacksonville, FL
- Time: Sunday 1:00 p.m. ET
- Spread: SEA -1.5 | Total: 47.5
- Moneyline: SEA -110 | JAX – 110
Bettors expect this to be a flat spot for the Jags. But an early start sinks the Seahawks in this non-conference battle.
Predicted Outcome: Jaguars 31 – Seahawks 24
Los Angeles Chargers vs. Miami Dolphins
- Stadium: Hard Rock Stadium
- Location: Miami Gardens, FL
- Time: Sunday 1:00 p.m. ET
- Spread: LAC -3.5 | Total: 43.5
- Moneyline: LAC -200 | MIA +170
More travel and an early start for the Chargers. That leaves an edge in backing the underdog hosts in this one.
Predicted Outcome: Dolphins 21 – Chargers 20
New England Patriots vs. New Orleans Saints
- Stadium: Caesars Superdome
- Location: New Orleans, LA
- Time: Sunday 1:00 p.m. ET
- Spread: NE -3.5 | Total: 45.5
- Moneyline: NE -185 | NO +155
This is a classic letdown spot for the Pats. Nevertheless, the Saints won’t be marching over anyone on Sunday.
Predicted Outcome: Patriots 24 – Saints 20
Tennessee Titans vs. Las Vegas Raiders
- Stadium: Allegiant Stadium
- Location: Las Vegas, NV
- Time: Sunday 4:05 p.m. ET
- Spread: LV -3.5 | Total: 40.5
- Moneyline: LV -230 | TEN +195
The Raiders will be ready to defend their home turf against an uninspired Titans offense.
Predicted Outcome: Raiders 21 – Titans 10
Cincinnati Bengals vs. Green Bay Packers
- Stadium: Lambeau Field
- Location: Green Bay, WI
- Time: Sunday 4:25 p.m. ET
- Spread: GB -14.5 | Total: 44.5
- Moneyline: GB -1600 | CIN +800
The Bengals reaching 17 points against the Packers’ defense will be considered a win.
Predicted Outcome: Packers 31 – Bengals 17
Detroit Lions vs. Kansas City Chiefs
- Stadium: Arrowhead Stadium
- Location: Kansas City, MO
- Time: Sunday 8:20 p.m. ET
- Spread: KC -1.5 | Total: 52.5
- Moneyline: KC -130 | DET +110
These teams will be ready to shoot out the lights. Advantage, Lions.
Predicted Outcome: Lions 38 – Chiefs 35
Buffalo Bills vs. Atlanta Falcons
- Stadium: Mercedes-Benz Stadium
- Location: Atlanta, GA
- Time: Monday 7:15 p.m. ET
- Spread: BUF -4.5 | Total: 49.5
- Moneyline: BUF -215 | ATL +180
The Falcons are rested and come out firing on all cylinders. Bills close late but come up short.
Predicted Outcome: Falcons 28 – Bills 24
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