MLB Betting Guide for April 22: Mets, Phillies Chasing Braves

Ben DiGiacomo
Host · Writer

We have an 11-game MLB slate set for today, so let’s dive into all the action.
There is just a single afternoon game today as the New York Yankees will host the Oakland Athletics. The A’s have actually been putting up better fights than many think, so we’ll see if Carlos Rodon will be able to keep the Yankees momentum rolling.
Looking at the night slate, we’ll have our eyes on the NL East squads in action as while the Atlanta Braves‘ offense may be fueling their dominance, the Philadelphia Phillies and New York Mets are right on their tails. The Phils are on a six-game winning streak fueled by dominant pitching while the Mets have won eight of their last ten and just took a series from the mighty Los Angeles Dodgers. If Atlanta doesn’t improve their pitching staff, can either Philly or New York steal in the NL East?
Elsewhere on the slate, we have a few interesting matchups in the AL as the Kansas City Royals will host the Toronto Blue Jays while the Los Angeles Angels will host the Baltimore Orioles.
It will be a great weekend of baseball, so stay with SportsGrid to have you covered on everything today could throw at us. Let’s ride!
Swing for the Fences with SportsGrid’s free daily MLB Game Picks and MLB Prop Picks.
MLB Betting Guide for April 22
Tonight’s Headlines: Orioles & Burnes: Match Made in Heaven
Catch Up on Yesterday’s Action: Dodgers Bounce Back vs. Mets
1:05 p.m. ET: Oakland Athletics @ New York Yankees
- Run Line: Yankees -1.5 | Moneyline: Yankees -245 | Total: 8
- Where to Watch: MLB.TV | Location: Yankee Stadium (Bronx, NY)
- Weather Notes: Clear, winds blowing out to right
Starting Pitching Matchup: JP Sears (ERA: 4.36; K/9: 3.92) vs. Carlos Rodon (ERA: 3.66; K/9: 8.24)
SportsGrid’s Best Bets: A’s +1.5 (4.5-Stars) | UNDER 8 (3.5-Stars)
SportsGrid’s Predicted Game Outcome: Yankees by 1 run
SportsGrid’s Top Props: Esteury Ruiz OVER 0.5 RBIs (5-Stars, +250) | Carlos Rodon UNDER 7.5 Ks (5-Stars)
6:40 p.m. ET: Milwaukee Brewers @ Pittsburgh Pirates
- Run Line: Pirates -1.5 | Moneyline: Pirates -132 | Total: 7.5
- Where to Watch: MLB.TV | Location: PNC Park (Pittsburgh, PA)
- Weather Notes: Clear, winds blowing out to left
Starting Pitching Matchup: Joe Ross (ERA: 4.91; K/9: 8.59) vs. Jared Jones (ERA: 3.13; K/9: 12.52)
SportsGrid’s Best Bets: Brewers ML (3-Stars, +112) | OVER 7.5 (5-Stars)
SportsGrid’s Predicted Game Outcome: Brewers by 1 run
SportsGrid’s Top Props: Joe Ross UNDER 5.5 Ks (5-Stars) | Jared Jones OVER 6.5 Ks (5-Stars)
6:40 p.m. ET: Philadelphia Phillies @ Cincinnati Reds
- Run Line: Phillies -1.5 | Moneyline: Phillies -122 | Total: 8.5
- Where to Watch: MLB.TV | Location: Great American Ball Park (Cincinnati, OH)
- Weather Notes: Clear, winds blowing in from right
Starting Pitching Matchup: Ranger Suarez (ERA: 1.73; K/9: 9.35) vs. Hunter Greene (ERA: 4.36; K/9: 13.06)
SportsGrid’s Best Bets: Reds +1.5 (3.5-Stars) | OVER 8.5 (3.5-Stars)
SportsGrid’s Predicted Game Outcome: Reds by 1 run
SportsGrid’s Top Props: Brandon Marsh OVER 0.5 RBIs (5-Stars, +210) | Spencer Steer OVER 0.5 RBIs (5-Stars, +170)
6:50 p.m. ET: Detroit Tigers @ Tampa Bay Rays
- Run Line: Tigers -1.5 | Moneyline: Tigers -108 | Total: 7.5
- Where to Watch: MLB.TV | Location: Tropicana Field (St. Petersburg, FL)
- Weather Notes: Dome
Starting Pitching Matchup: Tarik Skubal (ERA: 2.28; K/9: 9.89) vs. Zack Littell (ERA: 2.14; K/9: 9.43)
SportsGrid’s Best Bets: Rays ML (3-Stars) | OVER 7.5 (4-Stars)
SportsGrid’s Predicted Game Outcome: Rays by 2 runs
SportsGrid’s Top Props: Matt Vierling OVER 0.5 Runs (5-Stars, +140) | Zack Littell UNDER 5.5 Ks (5-Stars)
7:20 p.m. ET: Miami Marlins @ Atlanta Braves
- Run Line: Braves -1.5 | Moneyline: Braves -205 | Total: 9.5
- Where to Watch: MLB.TV | Location: Truist Park (Atlanta, GA)
- Weather Notes: Clear, winds blowing out to left-cetnter
Starting Pitching Matchup: Ryan Weathers (ERA: 2.70; K/9: 9.90) vs. Bryce Elder
SportsGrid’s Best Bet: Braves -1.5 (4-Stars) | OVER 9.5 (3-Stars)
SportsGrid’s Predicted Game Outcome: Braves by 2 runs
SportsGrid’s Top Props: Ryan Weathers UNDER 4.5 Ks (5-Stars) | Marcell Ozuna OVER 0.5 RBIs (5-Stars, +105)
7:40 p.m. ET: Detroit Tigers @ Minnesota Twins
- Run Line: Twins -1.5 | Moneyline: Twins -184 | Total: 8.5
- Where to Watch: MLB.TV | Location: Target Field (Minneapolis, MN)
- Weather Notes: Clear, winds blowing out to left-center
Starting Pitching Matchup: Jonathan Cannon (ERA: 1.80; K/9: 5.40) vs. Chris Paddack (ERA: 8.36; K/9: 5.79)
SportsGrid’s Best Bets: Twins -1.5 (4.5-Stars) | UNDER 8.5 (1-Star)
SportsGrid’s Predicted Game Outcome: Twins by 2 runs
SportsGrid’s Top Props: Jonathan Cannon UNDER 4.5 Ks (5-Stars) | Chris Paddack UNDER 4.5 Ks (5-Stars)
7:40 p.m. ET: Toronto Blue Jays @ Kansas City Royals
- Run Line: Blue Jays -1.5 | Moneyline: Blue Jays -118 | Total: 9
- Where to Watch: MLB.TV | Location: Kauffman Stadium (Kansas City, MO)
- Weather Notes: Clear, warm, winds blowing out to left
Starting Pitching Matchup: Yusei Kikuchi (ERA: 2.08; K/9: 12.05) vs. Brady Singer (ERA: 1.54; K/9: 8.87)
SportsGrid’s Best Bet: UNDER 9 (1-Star)
SportsGrid’s Predicted Game Outcome: Blue Jays by 1 run
SportsGrid’s Top Props: Alejandro Kirk OVER 0.5 RBIs (2.5-Stars, +170) | Salvador Perez OVER 0.5 RBIs (4.5-Stars, +110)
7:45 p.m. ET: Arizona Diamondbacks @ St. Louis Cardinals
- Run Line: Diamondbacks -1.5 | Moneyline: Diamondbacks -108 | Total: 8.5
- Where to Watch: MLB.TV | Location: Busch Stadium (St. Louis, MO)
- Weather Notes: Clear, winds blowing out to left
Starting Pitching Matchup: Brandon Pfaadt (ERA: 5.32; K/9: 8.75) vs. Lance Lynn (ERA: 2.18; K/9: 8.27)
SportsGrid’s Best Bets: Diamondbacks ML (4-Stars) | UNDER 8.5 (2-Stars)
SportsGrid’s Predicted Game Outcome: Diamondbacks by 2 runs
SportsGrid’s Top Props: Blaze Alexander OVER 0.5 RBIs (5-Stars, +250) | Lance Lynn UNDER 5.5 Ks (3-Stars)
8:40 p.m. ET: San Diego Padres @ Colorado Rockies
- Run Line: Padres -1.5 | Moneyline: Padres -196 | Total: 10.5
- Where to Watch: MLB.TV | Location: Coors Field (Denver, CO)
- Weather Notes: Clear, winds blowing from left to right
Starting Pitching Matchup: Dylan Cease (ERA: 1/99; K/9: 10.72) vs. Austin Gomber (ERA: 4.95; K/9: 8.10)
SportsGrid’s Best Bet: UNDER 10.5 (3-Stars)
SportsGrid’s Predicted Game Outcome: Padres by 2 runs
SportsGrid’s Top Props: DyDylan Ceaselan Cease UNDER 7.5 Ks (4.5-Stars)
9:38 p.m. ET: Baltimore Orioles @ Los Angeles Angels
- Run Line: Angels +1.5 | Moneyline: Angels -118 | Total: 8.5
- Where to Watch: MLB.TV | Location: Angel Stadium (Anaheim, CA)
- Weather Notes: Clear, winds blowing out to left
Starting Pitching Matchup: Albert Suarez (ERA: 0.00; K/9: 6.35) vs. Reid Detmers (ERA: 1.19; K/9: 11.91)
SportsGrid’s Best Bets: Orioles ML (2-Stars, +100) | OVER 8.5 (4-Stars)
SportsGrid’s Predicted Game Outcome: Orioles by 1 run
SportsGrid’s Top Props: Gunnar Henderson OVER 0.5 RBIs (5-Stars, +190) | Taylor Ward OVER 0.5 RBIs (5-Stars, +155)
9:45 p.m. ET: New York Mets @ San Francisco Giants
- Run Line: Giants -1.5 | Moneyline: Giants -126 | Total: 7.5
- Where to Watch: MLB.TV| Location: Oracle Park (San Francisco, CA)
- Weather Notes: Clear, winds blowing out to left
Starting Pitching Matchup: Jose Quintana (ERA: 3.05; K/9: 6.97) vs. Keaton Winn (ERA: 4.09; K/9: 6.95)
SportsGrid’s Best Bets: Mets ML (3-Stars) | OVER 7.5 (2-Stars)
SportsGrid’s Predicted Game Outcome: Mets by 2 runs
SportsGrid’s Top Props: Brandon Nimmo OVER 0.5 RBIs (5-Stars, +200) | Jung Hoo Lee OVER 0.5 Hits (5-Stars)
