NFL Odds Week 1: Biggest NFL Spreads This Week

Week 1 of the NFL regular season is upon us, and some sizable spreads are on the board. What are the biggest spreads for Week 1 of the NFL campaign?

Here’s a look at Week 1 NFL odds to see who the most significant favorites are. 

NFL Odds Week 1: Biggest NFL Spreads This Week

Rank	Matchup	Spread
1	Houston Texans vs. Baltimore Ravens	Ravens -10
2	Arizona Cardinals vs. Washington Commanders	Commanders -7
3	Detroit Lions vs. Kansas City Chiefs	Chiefs -6.5
4	Tampa Bay Buccaneers vs. Minnesota Vikings	Vikings -6
5	Los Angeles Rams vs. Seattle Seahawks	Seahawks -5.5
6	Jacksonville Jaguars vs. Indianapolis Colts	Jaguars -4.5
7	Philadelphia Eagles vs. New England Patriots	Eagles -4
8. (Tie)	Carolina Panthers vs. Atlanta Falcons	Falcons -3.5
8. (Tie)	Las Vegas Raiders vs. Denver Broncos	Broncos -3.5
10. (Tie)	Tennessee Titans vs. New Orleans Saints	Saints -3
10. (Tie)	Miami Dolphins vs. Los Angeles Chargers	Chargers -3
10. (Tie)	Dallas Cowboys vs. New York Giants	Cowboys -3

1. Houston Texans vs. Baltimore Ravens (-10)

The largest spread of Week 1 goes to the Baltimore Ravens and Houston Texans. Lamar Jackson and the Ravens are double-digit favorites over the Texans at -10. In 2022, Baltimore posted an 8-9-1 record against the spread. 

2. Arizona Cardinals vs. Washington Commanders (-7)

The Arizona Cardinals and Washington Commanders have the second-largest spread of Week 1. The Commanders are seven-point home favorites over the Cardinals and finished 2022 with an 8-8-1 record against the spread. 

3. Detroit Lions vs. Kansas City Chiefs (-6.5)

Thursday Night Football action kicks off with a bang as the Kansas City Chiefs’ Super Bowl title defense begins at home vs. the Detroit Lions. Patrick Mahomes and company are listed as 6.5-point home favorites. In 2022, the Chiefs finished near the bottom of the league against the spread with an 8-11-1 record. 

4. Tampa Bay Buccaneers vs. Minnesota Vikings (-6)

The Minnesota Vikings and Tampa Bay Buccaneers will collide during Week 1 action from U.S. Bank Stadium. The Vikings won the NFC North in 2022 but struggled against the spread, where they posted a 7-10-1 record. The Vikings are six-point home favorites in Week 1 against the Bucs. 

5. Los Angeles Rams vs. Seattle Seahawks (-5.5)

NFC West foes are facing off in Week 1 action as the Seattle Seahawks play host to the Los Angeles Rams as 5.5-point home favorites. The Seahawks struggled against the spread in 2022, finishing the year 7-11. 

6. Jacksonville Jaguars (-4.5) vs. Indianapolis Colts

Two AFC South clubs are set to collide in Week 1 action, with the Indianapolis Colts playing host to the Jacksonville Jaguars. The Jaguars are listed as 4.5-point road favorites and finished last year 10-9 against the spread. 

7. Philadelphia Eagles (-4) vs. New England Patriots 

The Philadelphia Eagles are coming off a 2022 campaign where they won the NFC. The Eagles’ defense of the conference begins in Week 1 against the New England Patriots as four-point road favorites. The Eagles finished 2022 with a 10-10 record against the spread. 

8. (Tie) Carolina Panthers vs. Atlanta Falcons (-3.5)

Two NFC South clubs are set to match up during Week 1 action, with the Atlanta Falcons listed as a 3.5-point home favorite over the Carolina Panthers. The Falcons were 9-8 against the spread in 2022. 

8. (Tie) Las Vegas Raiders vs. Denver Broncos (-3.5)

An AFC West matchup will go down during Week 1 as the Las Vegas Raiders visit the Denver Broncos. Sean Payton and the Broncos are listed as 3.5-point home favorites and finished the 2022 campaign 7-10 against the spread. 

10. (Tie) Tennessee Titans vs. New Orleans Saints (-3)

Week 1 has the Tennessee Titans visiting the New Orleans Saints. The Saints aim to capture the NFC South and are three-point home favorites. In 2022, the Saints finished 7-10 against the spread. 

10. (Tie) Miami Dolphins vs. Los Angeles Chargers (-3)

The Los Angeles Chargers face off with the Miami Dolphins in Week 1 action. The Chargers were strong in 2022 against the spread, finishing the year 11-6-1. Los Angeles is listed as a three-point home favorite. 

10. (Tie) Dallas Cowboys (-3) vs. New York Giants 

In 2022, the Dallas Cowboys won both meetings over the New York Giants. They’re set to enter this Week 1 NFC East battle as a three-point road favorite from MetLife Stadium. The Cowboys finished 2022 11-6 against the spread. 

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