NFL Week 16 MNF: Who’s Scoring Tonight? Best Anytime TD Picks for 49ers vs Colts
Paul Connor
Host · Writer
Week 16 in the NFL concludes with an interconference matchup as Philip Rivers and the Indianapolis Colts (8-6) host Christian McCaffrey and the San Francisco 49ers (10-4) on Monday Night Football.
The 49ers, who have won four straight games, are currently booked as 5.5-point favorites. Meanwhile, the Colts are riding a four-game losing streak as they navigate the season-ending injury to quarterback Daniel Jones.
With the stage set, here are my top anytime touchdown scorer props for the action!
Note: All odds are courtesy of FanDuel Sportsbook and are subject to change after the publication of this article.
1. SF WR Jauan Jennings (+160)
Few receivers in football are running hotter than Jennings right now. The Tennessee product has found the end zone in three straight games and five of his last six, highlighted by a two-touchdown outing in last week’s victory. Jennings paces San Francisco in both receiving touchdowns (7) and red-zone targets (16), and his role should only grow with Ricky Pearsall (knee/ankle) sidelined. At plus money, banking on Jennings to continue his TD streak is one of the best values on the board.
2. IND WR Michael Pittman Jr. (+350)
San Francisco entered Week 16 having allowed the fourth-most passing touchdowns (25). While the Colts’ passing volume is more controlled with Rivers under center, Pittman remains the undisputed alpha in high-leverage situations. The 6’4" wideout leads the team with seven receiving touchdowns and has consistently been featured near the goal line, drawing 12 red zone targets on the year. Against a 49ers secondary that has struggled to defend the boundary, Pittman’s size and catch radius create a mismatch that’s hard to ignore at this price.
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