MLB Betting Guide for May 22: Braves A Tough Price to Back

Ben DiGiacomo
Host · Writer

All 30 MLB teams are in action today, so let’s dive into everything you need to know for the day ahead.
Kicking off the day, tonight is a mini-doubleheader in St. Louis. The Baltimore Orioles and St. Louis Cardinals need to resume their game from last night, which was suspended due to rain. Action will pick up in the middle of the 6th inning, tied 1-1, before the two teams pick up with their regularly scheduled game later in the afternoon.
Additionally, in the early window, the Houston Astros will hope to continue to accumulate wins and regain footing in the AL West as they host the Los Angeles Angels. At the same time, the Detroit Tigers and Kansas City Royals will square off, with AL Cy Young hopeful Tarik Skubal taking the mound.
Later, the Philadelphia Phillies will look to build on their MLB-leading 35th win from last night against the Texas Rangers once again, and the New York Yankees will aim to get back in the win column against the Seattle Mariners after dropping the first two games of the series.
Lastly, the Atlanta Braves remain in Wrigley Field to face the Chicago Cubs after another ugly loss last night. The Braves have now lost five of their last six, and with the Phillies leading them by six games in the NL East, the idea of a rebound is starting to feel less and less likely. The Braves boast the offensive talent necessary to overcome, and it’s a long season, but the vibes aren’t the same as in past years. The Braves are still priced second behind the Los Angeles Dodgers to claim the NL pennant, but it’s hard to back that price with the current product.
It will be a great night of baseball, so stay with SportsGrid to have you covered on everything that could be thrown at us today. Let’s ride!
Swing for the Fences with SportsGrid’s free daily MLB Game Picks and MLB Prop Picks.
MLB Betting Guide for May 22
Tonight’s Headliners: World Series Futures Analysis | Yankees Ticket Revenue Look-In
Catch Up on the Weekend’s Action: Phils Win 35th Win | Astros Win vs. Angels in Extras | D-Backs Comeback vs. Dodgers
Game to be Resumed at 12:15 p.m. ET: Baltimore Orioles @ St. Louis Cardinals
- Mid-6th, Game Tied at 1-1
1:05 p.m. ET: Minnesota Twins @ Washington Nationals
- Run Line: Twins -1.5 | Moneyline: Twins -136 | Total: 9
- Where to Watch: MLB.TV | Location: Nationals Park (Washington, D.C.)
- Weather Notes: Clear, winds blowing out to center
Starting Pitching Matchup: Simeon Woods Richardson (ERA: 2.97; K/9: 7.42) vs. Jake Irvin (ERA: 3.91; K/9: 6.75)
SportsGrid’s Best Bet: UNDER 9.5 (1.5-Stars)
SportsGrid’s Predicted Game Outcome: Twins by 0.7 Runs
SportsGrid’s Top Props: Ryan Jeffers OVER 0.5 RBIs (5-Stars, +135) | Joey Meneses OVER 0.5 RBIs (5-Stars, +155)
1:10 p.m ET: New York Mets @ Cleveland Guardians
- Run Line: Guardians +1.5 | Moneyline: Guardians -126 | Total: 9
- Where to Watch: MLB.TV | Location: Progressive Field (Cleveland, OH)
- Weather Notes: Rain showers expected throughout, a delay is likely
Starting Pitching Matchup: Jose Quintana (ERA: 5.21; K/9: 6.17) vs. Triston McKenzie (ERA: 3.23; K/9: 7.61)
SportsGrid’s Best Bets: Guardians -1.5 (1-Star) | UNDER 9 (2-Stars)
SportsGrid’s Predicted Game Outcome: Guardians by 0.7 Runs
SportsGrid’s Top Props: Francisco Lindor OVER 0.5 RBIs (5-Stars, +155) | Jose Ramirez OVER 0.5 RBIs (5-Stars, +115)
2:10 p.m. ET: Los Angeles Angels @ Houston Astros
- Run Line: Astros -1.5 | Moneyline: Astros -178 | Total: 9
- Where to Watch: MLB.TV | Location: Minute Maid Park (Houston, TX)
- Weather Notes: Dome
Starting Pitching Matchup: Tyler Anderson (ERA: 2.72; K/9: 6.39) vs. Hunter Brown (ERA: 7.71; K/9: 9.88)
SportsGrid’s Best Bets: Angels +1.5 (3-Stars) | Angels (4-Stars, +150) | UNDER 9 (3-Stars)
SportsGrid’s Predicted Game Outcome: Even
SportsGrid’s Top Props: Tyler Anderson OVER 3.5 Ks (4.5-Stars) | Hunter Brown UNDER 5.5 Ks (3.5-Stars)
2:10 p.m. ET: Detroit Tigers @ Kansas City Royals
- Run Line: Tigers -1.5 | Moneyline: Tigers -116 | Total: 7.5
- Where to Watch: MLB.TV | Location: Kaufman Stadium (Kansas City, MO)
- Weather Notes: Clear, winds blowing across from left to right
Starting Pitching Matchup: Tarik Skubal (ERA: 1.80; K/9: 10.80) vs. Cole Ragans (ERA: 3.70; K/9: 10.29)
SportsGrid’s Best Bets: Royals +1.5 (3-Stars) | Royals ML (3.5-Stars, +102) | OVER 7.5 (5-Stars)
SportsGrid’s Predicted Game Outcome: Royals by 0.8 runs
SportsGrid’s Top Props: Wenceel Perez OVER 0.5 RBIs (5-Stars, +185) | Cole Ragans OVER 6.5 Ks (5-Stars, +114)
Expected Start Time – 3:00 p.m. ET: Baltimore Orioles @ St. Louis Cardinals
- Run Line: Orioles -1.5 | Moneyline: Orioles -134 | Total: 8.5
- Where to Watch: MLB.TV | Location: Busch Stadium (St. Louis, MO)
- Weather Notes: Clear, winds blowing out to right
Starting Pitching Matchup: John Means (ERA: 3.06; K/9: 7.64) vs. Kyle Gibson (ERA: 4.09; K/9: 7.04)
SportsGrid’s Best Bets: Cardinals +1.5 (3-Stars) | UNDER 8.5 (1-Star)
SportsGrid’s Predicted Game Outcome: Cardinals by 0.1 Runs
SportsGrid’s Top Props: Gunnar Henderson OVER 0.5 RBIs (5-Stars, +140) | Pedro Pages OVER 0.5 RBIs (5-Stars, +260)
6:40 p.m ET: San Francisco Giants @ Pittsburgh Pirates
- Run Line: Pirates -1.5 | Moneyline: Pirates -124 | Total: 7.5
- Where to Watch: MLB.TV | Location: PNC Park (Pittsburgh, PA)
- Weather Notes: Potential for a spotty shower, a delay is still unlikely but still possible
Starting Pitching Matchup: Blake Snell (ERA: 11.57; K/9: 9.26) vs. Jared Jones (ERA: 2.89; K/9: 10.70)
SportsGrid’s Best Bets: Giants ML (3-Stars) | OVER 7.5 (2.5-Stars)
SportsGrid’s Predicted Game Outcome: Giants by 0.4 Runs
SportsGrid’s Top Props: Blake Snell OVER 5.5 Ks (5-Stars) | Bryan Reynolds OVER 0.5 RBIs (5-Stars, +175)
6:40 p.m ET: Texas Rangers @ Philadelphia Phillies
- Run Line: Phillies -1.5 | Moneyline: Phillies -134 | Total: 9.5
- Where to Watch: MLB.TV | Location: Citizens Bank Park (Philadelphia, PA)
- Weather Notes: Clear, winds blowing out to center
Starting Pitching Matchup: Dane Dunning (ERA: 4.10; K/9: 10.37) vs. Taijuan Walker (ERA: 4.91; K/9: 6.55)
SportsGrid’s Best Bets: Rangers ML (3-Stars, +114) | UNDER 9.5 (1-Star)
SportsGrid’s Predicted Game Outcome: Rangers by 0.4 Runs
SportsGrid’s Top Props: Marcus Semien OVER 0.5 RBIs (5-Stars, +145) | Alec Bohm OVER 0.5 RBIs (5-Stars, +125)
6:40 p.m. ET: Milwaukee Brewers @ Miami Marlins
- Run Line: Brewers -1.5 | Moneyline: Brewers -144 | Total: 7.5
- Where to Watch: MLB.TV | Location: loanDepot Park (Miami, FL)
- Weather Notes: Dome
Starting Pitching Matchup: Freddy Peralta (ERA: 4.17; K/9: 11.60) vs. Jesus Luzardo (ERA: 5.02; K/9: 10.04)
SportsGrid’s Best Bets: Brewers -1.5 (3-Stars) | Brewers ML (4-Stars) | OVER 7.5 (5-Stars)
SportsGrid’s Predicted Game Outcome: Brewers by 1.7 Runs
SportsGrid’s Top Props: William Contreras OVER 0.5 RBIs (5-Stars, +160) | Jake Burger OVER 0.5 RBIs (5-Stars, +190)
6:40 p.m. ET: San Diego Padres @ Cincinnati Reds
- Run Line: Padres -1.5 | Moneyline: Padres -124 | Total: 9.5
- Where to Watch: MLB.TV | Location: Great American Ball Park (Cincinnati, OH)
- Weather Notes: Clear, winds blowing across from right to left
Starting Pitching Matchup: Michael King (ERA: 4.31; K/9: 10.10) vs. Nick Martinez (ERA: 4.23; K/9: 6.81)
SportsGrid’s Best Bets: Padres ML (5-Stars) | UNDER 9.5 (5-Stars)
SportsGrid’s Predicted Game Outcome: Padres by 1.7 Runs
SportsGrid’s Top Props: Jake Cronenworth OVER 0.5 RBIs (5-Stars, +125) | Nick Martinez OVER 3.5 Ks (5-Stars)
6:50 p.m. ET: Boston Red Sox @ Tampa Bay Rays
- Run Line: Rays -1.5 | Moneyline: Rays -124 | Total: 7.5
- Where to Watch: MLB.TV | Location: Tropicana Field (St. Petersburg, FL)
- Weather Notes: Dome
Starting Pitching Matchup: Brayan Bello (ERA: 3.96; K/9: 7.68) vs. Ryan Pepiot (ERA: 3.68; K/9: 10.06)
SportsGrid’s Best Bet: OVER 7.5 (2-Stars)
SportsGrid’s Predicted Game Outcome: Rays by 0.2 Runs
SportsGrid’s Top Props: Rafael Devers OVER 0.5 RBIs (5-Stars, +130) | Ryan Pepiot UNDER 5.5 Ks (4-Stars)
7:05 p.m. ET: Seattle Mariners @ New York Yankees
- Run Line: Yankees -1.5 | Moneyline: Yankees -158 | Total: 8
- Where to Watch: MLB.TV | Location: Yankee Stadium (Bronx, NY)
- Weather Notes: Clear, winds blowing across from right to left
Starting Pitching Matchup: Bryce Miller (ERA: 3.08; K/9: 8.89) vs. Nestor Cortes (ERA: 3.56; K/9: 8.46)
SportsGrid’s Best Bets: Mariners +1.5 (5-Stars) | Mariners ML (5-Stars, +134) | UNDER 8 (1-Star)
SportsGrid’s Predicted Game Outcome: Mariners by 1.6 runs
SportsGrid’s Top Props: Mitch Garver OVER 0.5 RBIs (5-Stars, +165) | Alex Verdugo OVER 0.5 RBIs (5-Stars, +170)
7:07 p.m. ET: Chicago White Sox @ Toronto Blue Jays
- Run Line: Blue Jays -1.5 | Moneyline: Blue Jays -235 | Total: 8.5
- Where to Watch: ESPN+ | Location: Rogers Centre (Toronto, ON)
- Weather Notes: Dome
Starting Pitching Matchup: Nick Nastrini (ERA: 7.88; K/9: 9.00) vs. Chris Bassitt (ERA: 5.03; K/9: 8.38)
SportsGrid’s Best Bet: OVER 8.5 (3-Stars)
SportsGrid’s Predicted Game Outcome: Blue Jays by 1.6 Runs
SportsGrid’s Top Props: Andrew Benintendi OVER 0.5 RBIs (5-Stars, +190) | Danny Jansen OVER 0.5 RBIs (5-Stars, +150)
7:40 p.m. ET: Atlanta Braves @ Chicago Cubs
- Run Line: Braves -1.5 | Moneyline: Braves -138 | Total: 8.5
- Where to Watch: MLB.TV | Location: Wrigley Field (Chicago, IL)
- Weather Notes: Clear, winds blowing out to right
Starting Pitching Matchup: Max Fried (ERA: 3.81; K/9: 7.07) vs. Justin Steele (ERA: 5.21; K/9: 8.53)
SportsGrid’s Best Bets: Braves -1.5 (4-Stars) | Braves ML (5-Stars) | UNDER 8.5 (2-Stars)
SportsGrid’s Predicted Game Outcome: Braves by 2.1 runs
SportsGrid’s Top Props: Marcell Ozuna OVER 0.5 RBIs (5-Stars, +110) | Christopher Morel OVER 0.5 RBIs (5-Stars, +160)
9:40 p.m. ET: Colorado Rockies @ Oakland Athletics
- Run Line: Athletics -1.5 | Moneyline: Athletics -126 | Total: 8
- Where to Watch: MLB.TV | Location: Oakland Coliseum (Oakland, CA)
- Weather Notes: Clear, winds blowing out to center
Starting Pitching Matchup: Austin Gomber (ERA: 3.02; K/9: 6.22) vs. Mitch Spence (ERA: 3.90; K/9: 7.80)
SportsGrid’s Best Bets: Rockies ML (2-Stars, +108) | OVER 8 (2-Stars)
SportsGrid’s Predicted Game Outcome: Rockies by 0.1 runs
SportsGrid’s Top Props: Austin Gomber UNDER 4.5 Ks (5-Stars) | Shea Langeliers OVER 0.5 RBIs (5-Stars, +145)
10:10 p.m. ET: Arizona Diamondbacks @ Los Angeles Dodgers
- Run Line: Dodgers -1.5 | Moneyline: Dodgers -270 | Total: 8.5
- Where to Watch: MLB.TV | Location: Dodger Stadium (Los Angeles, CA)
- Weather Notes: Clear, winds blowing out to center
Starting Pitching Matchup: Ryne Nelson (ERA: 7.06; K/9: 7.06) vs. Tyler Glasnow (ERA: 2.90; K/9: 11.76)
SportsGrid’s Best Bets: Diamondbacks +1.5 (4-Stars) | OVER 8.5 (1-Star)
SportsGrid’s Predicted Game Outcome: Dodgers by 1 run
SportsGrid’s Top Props: Christian Walker OVER 0.5 RBIs (5-Stars, +200)
All Odds Courtesy of FanDuel Sportsbook
