3. Iowa State Cyclones (+400)
If you prefer a battle-tested defense for your NCAA dark horse team, turn your attention to the Big 12 and the Iowa State Cyclones. TJ Otzelberger’s squad allows only 62.9 points per game and is in second place in the nation’s toughest conference. The Cyclones have wins over Houston, TCU, Kansas, TCU, and Texas Tech, with the ability to win away from Ames. This is a balanced squad with five players averaging 9.5 points per game or more. Iowa State is not a household name, but this veteran team can frustrate opponents, and a run to the Final Four would not be shocking.