49ers vs. Cardinals: Week 5 Betting Preview and Key Matchups

The San Francisco 49ers head into Week 5 as heavy favorites against the Arizona Cardinals, with a spread set at -7.5 and an enticing total of 48.5 points. The Cardinals’ defense, led by head coach Jonathan Gannon, has struggled to contain opposing offenses, living up to its preseason billing as one of the weakest defensive units in the NFL. With the Niners boasting one of the most balanced offenses in the league, quarterback Brock Purdy is poised for a big game as San Francisco looks to put up points in bunches.

Tackle the Odds with SportsGrid’s Expert NFL Game Picks and NFL Player Prop Picks.

Betting Insights: Expecting a Big Day for the 49ers Offense

Key Betting Insights:

• Brock Purdy Passing Yards Prop: With Arizona’s defense failing to impress, betting on Brock Purdy to exceed his passing yards prop (usually around 259.5) is a solid play. Purdy has shown he can spread the ball effectively, especially with weapons like Deebo Samuel, Brandon Aiyuk, and George Kittle at his disposal.
• Over 48.5 Total Points: San Francisco’s offense has been dominant, and with Arizona’s defensive struggles, there’s a high chance the Niners will push the game into the 30-point range. Betting the over on the 48.5-point total could be a smart move, as the Niners could hit that number even if the Cardinals struggle to score.
• Deebo Samuel Anytime Touchdown: Arizona has been vulnerable to opposing teams’ top wide receivers. With Samuel expected to play a major role in the offense, betting on him to find the end zone is a strong play. The Cardinals have allowed multiple touchdowns to No. 1 receivers this season, which bodes well for Samuel.

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Fantasy Football and DFS Picks for 49ers vs Cardinals

In terms of fantasy football and DFS, Brock Purdy is a great value play this week. With the Cardinals’ porous defense, Purdy has the potential to surpass 300 passing yards and throw multiple touchdowns. Both Deebo Samuel and Brandon Aiyuk are must-starts in all formats, as they should feast on Arizona’s weak secondary.

Additionally, Jordan Mason is an interesting DFS play if you’re looking for value at running back. With Christian McCaffrey out, the 49ers will likely lean on Mason to control the tempo and could find the end zone in a high-scoring affair.

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San Francisco 49ers Betting Picks for Week 5

• Bet on Brock Purdy Over 259.5 Passing Yards: With Arizona’s defense struggling, Purdy is in prime position to light up the stat sheet. Betting on him to exceed 259.5 passing yards offers great value, especially with the variety of weapons at his disposal.
• Deebo Samuel Anytime Touchdown: Samuel is expected to be heavily involved in the offense, and Arizona’s defense has a history of allowing touchdowns to top receivers. A bet on Samuel to score is one of the best prop bets for this game.
• Over 48.5 Total Points: San Francisco is likely to score in the 30s, and while Arizona’s offense isn’t expected to put up big numbers, the Niners could still push the total over. Betting on the over offers solid value, given the mismatch between the Niners’ offense and the Cardinals’ defense.

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Final Thoughts: Niners to Dominate Behind Brock Purdy

The San Francisco 49ers are expected to dominate the Arizona Cardinals in Week 5, thanks to their high-powered offense and the Cardinals’ defensive struggles. Brock Purdy is primed for a big game, and the Niners should be able to exploit Arizona’s weaknesses both through the air and on the ground. For bettors, the over on the point total and Brock Purdy’s passing yards prop are great value bets.

Injuries to players like Christian McCaffrey haven’t slowed down San Francisco’s offense, and the additional reliance on players like Deebo Samuel, Brandon Aiyuk, and George Kittle makes the 49ers a difficult team to stop. Week 5 presents a great opportunity for the 49ers to continue their winning ways while providing several profitable betting angles.

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