NFL Week 1 Betting Lines: Biggest NFL Underdogs This Week

With so much parity in the NFL, the phrase “Any Given Sunday” applies on the gridiron with upsets every week. When betting on the NFL, this is always something to consider.

Below are the biggest underdogs of the week.

Rank	Matchup	Favorite	Underdog
1	Houston Texans vs. Baltimore Ravens	Ravens -10	Texans +10
2	Arizona Cardinals vs. Washington Commanders	Commanders -7	Cardinals +7
3	Detroit Lions vs. Kansas City Chiefs	Chiefs -6.5	Lions +6.5
4	Tampa Bay Buccaneers vs. Minnesota Vikings	Vikings -6	Buccaneers +6
5	Los Angeles Rams vs. Seattle Seahawks	Seahawks -5.5	Rams +5.5
6	Jacksonville Jaguars vs. Indianapolis Colts	Jaguars -4.5	Colts +4.5
7	Philadelphia Eagles vs. New England Patriots	Eagles -4	Patriots +4
8. (Tie)	Carolina Panthers vs. Atlanta Falcons	Falcons -3.5	Panthers +3.5
8. (Tie)	Las Vegas Raiders vs. Denver Broncos	Broncos -3.5	Raiders +3.5
10. (Tie)	Tennessee Titans vs. New Orleans Saints	Saints -3	Titans +3
10. (Tie)	Miami Dolphins vs. Los Angeles Chargers	Chargers -3	Dolphins +3
10. (Tie)	Dallas Cowboys vs. New York Giants	Cowboys -3	Gants +3

1. Houston Texans (+10) vs. Baltimore Ravens (-10)

Looking at the title for the biggest underdog of Week 1, that goes to the Houston Texans. The Texans are ten-point underdogs on the road against the Baltimore Ravens. Houston finished 2022 with an 8-8-1 record against the spread. 

2. Arizona Cardinals (+7) vs. Washington Commanders (-7)

The Arizona Cardinals are the second-biggest underdogs in Week 1 when visiting the Washington Commanders. The Cardinals are seven-point underdogs and registered an 8-9 record against the spread in 2022. 

3. Detroit Lions (+6.5) vs. Kansas City Chiefs (-6.5)

The Detroit Lions will watch the Kansas City Chiefs raise another Super Bowl banner on Thursday Night Football, where the visitors are listed as 6.5-point underdogs. Dan Campbell and the Lions were 12-5 against the spread in 2022. 

4. Tampa Bay Buccaneers (+6) vs. Minnesota Vikings (-6)

Without Tom Brady as their quarterback, the Tampa Bay Buccaneers are being led into Week 1 against the Minnesota Vikings with Baker Mayfield as their signal-caller. Mayfield and company are six-point road underdogs and were an NFL-worst 4-13-1 against the spread last year. 

5. Los Angeles Rams (+5.5) vs. Seattle Seahawks (-5.5)

NFC West division rivals, the Los Angeles Rams and Seattle Seahawks are set to collide in Week 1. The Rams are listed as a 5.5-point road underdog and were 6-9-2 against the spread in 2022. 

6. Jacksonville Jaguars (-4.5) vs. Indianapolis Colts (+4.5)

The Indianapolis Colts and Jacksonville Jaguars will face off in a divisional Week 1 matchup. The Colts are listed as 4.5-point home underdogs and finished last season with a 6-11 record against the spread. 

7. Philadelphia Eagles (-4) vs. New England Patriots (+4)

Bill Belichick and the New England Patriots are placed on the board as four-point home underdogs in their matchup against the defending NFC champion Philadelphia Eagles. The Pats finished 2022 with a 7-9-1 record against the spread. 

8. (Tie) Carolina Panthers (+3.5) vs. Atlanta Falcons (-3.5)

The Carolina Panthers and Atlanta Falcons begin their quests to come out on top in the NFC South during Week 1 action. The Panthers are listed as a 3.5-point underdog and compiled a 9-8 record against the spread in 2022. 

8. (Tie) Las Vegas Raiders (+3.5)  vs. Denver Broncos (-3.5)

An AFC West matchup between the Las Vegas Raiders and Denver Broncos has Jimmy Garoppolo and the Raiders listed as a 3.5-point underdog. The Raiders registered an 8-9 record against the spread in 2022. 

10. (Tie) Tennessee Titans (+3) vs. New Orleans Saints (-3)

The Tennessee Titans finished the 2022 campaign on a significant losing streak. They’re set to begin the 2023 regular season as a three-point underdog on the road in New Orleans. Tennessee compiled a 9-7-1 record against the spread in 2022. 

10. (Tie) Miami Dolphins (+3) vs. Los Angeles Chargers (-3)

The Miami Dolphins and Los Angeles Chargers faced off in 2022, which saw the Chargers outlast the Dolphins 23-17. The Dolphins are three-point underdogs and finished 2022 with a 10-8 record against the spread. 

10. (Tie) Dallas Cowboys (-3) vs. New York Giants (+3)

One of the biggest rivalries in the NFL will take center stage in Week 1 as the New York Giants host the Dallas Cowboys as three-point home underdogs. The Giants finished 2022 with an NFL-best 14-5 record against the spread. 

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