1. Penn State at West Virginia - August 31
There are not a lot of great non-conference games featuring Big 12 teams, but the week one matchup between Penn State and West Virginia in Morgantown is exempt from that criticism. This is a legitimately exciting clash. The two played last season in Happy Valley, and the Nittany Lions won. Still, it was not an exceptionally comfortable contest, and West Virginia put together a season more than good enough to remove head coach Neal Brown from the hot seat. Penn State is a preseason top-ten team and is favored going to Morgantown, but the Mountaineers have a shot in this one, and the atmosphere should be terrific. The Big 12 could undoubtedly use some marquee wins, and they don’t have many chances to grab one, so this game has gigantic ramifications for the league.
Penn State (-10.5) at West Virginia