NFL Week 4: Predicting the Outcomes of All 12 AFC Games

It’s a crucial week in the NFL, as several teams are still trying to salvage the start to the 2025 season. How do we see all 16 games unfolding in Week 4?

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Minnesota Vikings vs. Pittsburgh Steelers

• Stadium: Croke Park
• Location: Dublin, Ireland
• Time: Sunday 5:30 p.m. ET
• Spread: MIN -2.5 | Total: 40.5
• Moneyline: MIN -146 | PIT +124

Rookie quarterbacks rarely fare well against the Steelers.

Predicted Outcome: Steelers 20 – Vikings 10

New Orleans Saints vs. Buffalo Bills

• Stadium: Highmark Stadium
• Location: Orchard Park, NY
• Time: Sunday 1 p.m. ET
• Spread: BUF -15.5 | Total: 48.5
• Moneyline: BUF -1400 | NO +830

It’s time to start talking about which quarterback the Saints will draft with the first overall pick.

Predicted Outcome: Bills 35 – Saints 10

Tennessee Titans vs. Houston Texans

• Stadium: NRG Stadium
• Location: Houston, TX
• Time: Sunday 1 p.m. ET
• Spread: HOU -7.5 | Total: 38.5
• Moneyline: HOU -350 | TEN +280

It’s now or never for the Texans. Still, they probably aren’t as good as the betting line implies.

Predicted Outcome: Texans 24 – Titans 21

Cleveland Browns vs. Detroit Lions

• Stadium: Ford Field
• Location: Detroit, MI
• Time: Sunday 1 p.m. ET
• Spread: DET -9.5 | Total: 44.5
• Moneyline: DET -520 | CLE +400

The Lions still manage to catch teams off guard, and the Browns are no exception.

Predicted Outcome: Lions 38 – Browns 13

Carolina Panthers vs. New England Patriots

• Stadium: Gillette Stadium
• Location: Foxborough, MA
• Time: Sunday 1 p.m. ET
• Spread: NE -5.5 | Total: 43.5
• Moneyline: NE -250 | CAR +205

The Patriots aren’t 5.5 points better than anyone. Even the Panthers.

Predicted Outcome: Patriots 15 – Panthers 12

Los Angeles Chargers vs. New York Giants

• Stadium: MetLife Stadium
• Location: East Rutherford, NJ
• Time: Sunday 1 p.m. ET
• Spread: LAC -6.5 | Total: 44.5
• Moneyline: LAC -280 | NYG +230

Three road games in four weeks are no joke. The Chargers eke out a close one.

Predicted Outcome: Chargers 18 – Giants 17

Jacksonville Jaguars vs. San Francisco 49ers

• Stadium: Levi’s Stadium
• Location: Santa Clara, CA
• Time: Sunday 2:05 p.m. ET
• Spread: SF -3.5 | Total: 46.5
• Moneyline: SF -176 | JAX +148

The Niners have reached their breaking point. Jacksonville secures the unexpected win.

Predicted Outcome: Jaguars 24 – 49ers 20

Indianapolis Colts vs. Los Angeles Rams

• Stadium: SoFi Stadium
• Location: Inglewood, CA
• Time: Sunday 2:05 p.m. ET
• Spread: LAR -3.5 | Total: 49.5
• Moneyline: LAR -178 | IND +150

The Colts finally hit some resistance. Rams don’t let their offense get started.

Predicted Outcome: Rams 21 – Colts 10

Chicago Bears vs. Las Vegas Raiders

• Stadium: Allegiant Stadium
• Location: Las Vegas, NV
• Time: Sunday 2:25 p.m. ET
• Spread: LV -1.5 | Total: 47.5
• Moneyline: LV -110 | CHI -106

The Bears’ defensive line finally affords the Raiders’ offense time to move.

Predicted Outcome: Raiders 27 – Bears 21

Baltimore Ravens vs. Kansas City Chiefs

• Stadium: GEHA Field at Arrowhead Stadium
• Location: Kansas City, MO
• Time: Sunday 2:25 p.m. ET
• Spread: BAL -2.5 | Total: 48.5
• Moneyline: BAL -146 | KC +124

One of these powerhouses falls to 1-3. We’re betting it’s the Chiefs.

Predicted Outcome: Ravens 31 – Chiefs 28

New York Jets vs. Miami Dolphins

• Stadium: Hard Rock Stadium
• Location: Miami Gardens, FL
• Time: Monday 7:15 p.m. ET
• Spread: MIA -2.5 | Total: 44.5
• Moneyline: MIA -154 | NYJ +130

This will be the last time we see Mike McDaniel on the Dolphins’ sideline.

Predicted Outcome: Jets 31 – Dolphins 27

Cincinnati Bengals vs. Denver Broncos

• Stadium: Empower Field at Mile High Stadium
• Location: Denver, CO
• Time: Monday 8:15 p.m. ET
• Spread: DEN -7.5 | Total: 43.5
• Moneyline: DEN -370 | CIN +295

The Bengals’ offense is powerless against the Broncos’ defense.

Predicted Outcome: Denver 28 – Bengals 13

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