NFL Week 4: Predicting the Outcomes of All 12 NFC Games

It’s a crucial week in the NFL, as several teams are still trying to salvage the start to the 2025 season. How do we see all 16 games unfolding in Week 4?

Tackle the Odds with SportsGrid’s Expert NFL Game Picks and NFL Player Prop Picks.

Seattle Seahawks vs. Arizona Cardinals

• Stadium: State Farm Stadium
• Location: Glendale, AZ
• Time: Thursday 8:15 p.m. ET
• Spread: SEA -1.5 | Total: 43.5
• Moneyline: SEA -126 | ARI +108

The Seahawks are getting too much credit for their win last week. Cardinals cash as home underdogs.

Predicted Outcome: Cardinals 17 – Seahawks 14

Minnesota Vikings vs. Pittsburgh Steelers

• Stadium: Croke Park
• Location: Dublin, Ireland
• Time: Sunday 5:30 p.m. ET
• Spread: MIN -2.5 | Total: 40.5
• Moneyline: MIN -146 | PIT +124

It’s usually a tough time for quarterbacks facing Pittsburgh. Expect the Steelers to pressure the Vikings’ offense, which can’t possibly repeat last week’s explosion.

Predicted Outcome: Steelers 20 – Vikings 10

New Orleans Saints vs. Buffalo Bills

• Stadium: Highmark Stadium
• Location: Orchard Park, NY
• Time: Sunday 1 p.m. ET
• Spread: BUF -15.5 | Total: 48.5
• Moneyline: BUF -1400 | NO +830

It’s time to start talking about which quarterback the Saints will draft with the first overall pick.

Predicted Outcome: Bills 35 – Saints 10

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Cleveland Browns vs. Detroit Lions

• Stadium: Ford Field
• Location: Detroit, MI
• Time: Sunday 1 p.m. ET
• Spread: DET -9.5 | Total: 44.5
• Moneyline: DET -520 | CLE +400

The Lions still manage to catch teams off guard, and the Browns are no exception.

Predicted Outcome: Lions 38 – Browns 13

Washington Commanders vs. Atlanta Falcons

• Stadium: Mercedes-Benz Stadium
• Location: Atlanta, GA
• Time: Sunday 1 p.m. ET
• Spread: WSH -1.5 | Total: 45.5
• Moneyline: WSH -116 | ATL -102

If Washington hasn’t learned its lesson about rushing quarterbacks from injury by now, it never will.

Predicted Outcome: Falcons 20 – Commanders 16

Philadelphia Eagles vs. Tampa Bay Buccaneers

• Stadium: Raymond James Stadium
• Location: Tampa, FL
• Time: Sunday 1 p.m. ET
• Spread: PHI -3.5 | Total: 44.5
• Moneyline: PHI -194 | TB +162

The Eagles were fortunate to escape with the win last week. Their luck runs out in Tampa.

Predicted Outcome: Buccaneers 27 – Eagles 24

Carolina Panthers vs. New England Patriots

• Stadium: Gillette Stadium
• Location: Foxborough, MA
• Time: Sunday 1 p.m. ET
• Spread: NE -5.5 | Total: 43.5
• Moneyline: NE -250 | CAR +205

The Patriots aren’t 5.5 points better than anyone. Even the Panthers.

Predicted Outcome: Patriots 15 – Panthers 12

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Los Angeles Chargers vs. New York Giants

• Stadium: MetLife Stadium
• Location: East Rutherford, NJ
• Time: Sunday 1 p.m. ET
• Spread: LAC -6.5 | Total: 44.5
• Moneyline: LAC -280 | NYG +230

Three road games in four weeks are no joke. The Chargers eke out a close one.

Predicted Outcome: Chargers 18 – Giants 17

Jacksonville Jaguars vs. San Francisco 49ers

• Stadium: Levi’s Stadium
• Location: Santa Clara, CA
• Time: Sunday 2:05 p.m. ET
• Spread: SF -3.5 | Total: 46.5
• Moneyline: SF -176 | JAX +148

The Niners have reached their breaking point. Jacksonville secures the unexpected win.

Predicted Outcome: Jaguars 24 – 49ers 20

Indianapolis Colts vs. Los Angeles Rams

• Stadium: SoFi Stadium
• Location: Inglewood, CA
• Time: Sunday 2:05 p.m. ET
• Spread: LAR -3.5 | Total: 49.5
• Moneyline: LAR -178 | IND +150

The Colts finally hit some resistance. Rams don’t let their offense get started.

Predicted Outcome: Rams 21 – Colts 10

Chicago Bears vs. Las Vegas Raiders

• Stadium: Allegiant Stadium
• Location: Las Vegas, NV
• Time: Sunday 2:25 p.m. ET
• Spread: LV -1.5 | Total: 47.5
• Moneyline: LV -110 | CHI -106

The Bears’ defensive line finally affords the Raiders’ offense time to move.

Predicted Outcome: Raiders 27 – Bears 21

Green Bay Packers vs. Dallas Cowboys

• Stadium: AT&T Stadium
• Location: Arlington, TX
• Time: Sunday 8:20 p.m. ET
• Spread: GB -6.5 | Total: 47.5
• Moneyline: GB -330 | DAL +265

RIP Cowboys’ season. The Packers get back on track in a big way.

Predicted Outcome: Packers 35 – Cowboys 7

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