Contain Patrick Mahomes and Travis Kelce
The Kansas City Chiefs have built their dynasty on extracting maximum value from Patrick Mahomes. The two-time MVP has engineered all of the Chiefs' drives and points, often turning to Travis Kelce as his de facto passing option. Finding a way to corral both is essential for the San Francisco 49ers. 
Thankfully, a couple of teams have laid out the blueprints for how to contain Mahomes, and the answer is as simple as you may have thought -- you just have to disrupt his timing. 
In a 21-17 loss to the Philadelphia Eagles, Mahomes was hit nine times, forcing him to rush throws and make bad decisions. In that contest, the Chiefs quarterback completed 55.8% of throws for 177 yards. Subsequently, the Buffalo Bills held Mahomes to a 58.1% completion rate in Week 14, hitting him eight times. 
There's a reason why Mahomes is the betting favorite in the Super Bowl MVP market. He continues to thrive in the postseason, and in three playoff games, Mahomes has been sacked just twice and hit 15 times.
Nick Bosa and the 49ers defensive line have their work cut out for them, but they'll need to get to Mahomes to give their team a chance at walking away with the win.